[Receptors and mechanisms of neurotropic effects of cytokines and growth factors].

Cytokines and trophic factors (TF) are known to be involved not only into the immune processes but in majority cells, organs and physiological systems functional activity regulation as well as in pathological conditions. Cytokines and TF are shown to exert antagonistic effects on the brain, involved into local and systemic reactions modulation in response to CNS inflammation, infections and other types of injuries. Authors observed new data about cytokines and TF (particularly, the very biologically active among them - tumor necrosis factor-alpha and interleukin-1-beta) physico-chemical properties as the background for their neurotropic affects investigation.

[Neurotropic effects cytokines and trophic factors].

Cytokines and trophic factors (TF) are involved into the nervous system activity regulation that confirms by their secretion and receptors identification within nervous system. Cytokines and TF production increases tremendously in response to CNS alterations or other CNS pathologic events where they are modulated both alterative and protective effects. Authors observed the data of clinical and laboratory investigations concerning the cytokines and TF-neurotropic effects and also the original results dedicated to investigation of tumor necrosis factor-alpha and interleukin-1-beta influence on experimental seizure syndrome.

[The delta sleep-inducing peptide, its analogs and the serotoninergic system in the development of anticonvulsant action].

A seizure-protecting effect of the delta-sleep-inducing peptide (DSIP) and its analogues was revealed. An intensive sorption of H3 tryptophan occurred under the effect of the DSIP and its analogues. The data obtained suggests that the serotoninergic system plays no important part in the seizure-protecting effect.

[Effects of delta-sleep-inducing peptide during ischemic injury of the rat brain].

An anti-ischemic effect of the delta-sleep-inducing peptide (DSIP) was found in rats. The DSIP effect was more obvious than that of the MK-801. The data obtained is discussed considering a possible use of the DSIP for brain stroke prophylaxis.

[A rotational syndrome induced by administration of the delta sleep-inducing peptide into the reticular portion of the rat substantia nigra].

Unilateral intranigral administration of a delta-sleep-induced peptide (DSIP) evoked a contralateral rotation. Naloxon prevented development of the effect whereas haloperidol administration enhanced the DSIP cataleptogenic effect.

[The role of the delta sleep-inducing peptide in the formation of neuropathological syndromes].

The authors considered the pathogenetic role of delta-sleep inducing peptide (DSIP) in different neuropathological syndromes development and manifestation. According to own as well as published in the literature data authors showed the parkinsonian and the rotational syndromes development following DSIP central administration. Briefly, DSIP is a neuropeptide which play significant role in the mechanisms of development of different neuropathological syndromes, namely, epileptic, parkinsonian, withdrawal, rotational and others syndromes.

[The effect of the intranigral use of the delta sleep-inducing peptide and its analogs on the motor and seizure activities of rats].

The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats. It was shown that intranigral microinjection of DSIP as well as DSIP-1-DSIP-4 caused decreasing of horizontal, vertical locomotor activity and attendance of central sectors of the "open field". Antiseizure effects, i.

[The anticonvulsive action of the intranigral administration of the delta sleep-inducing peptide].

It is shown that injection of delta sleep-inducing peptide (DSIP) into the substantia nigra reticular part (SNrp) suppresses generalized convulsive activity induced in rats by picrotoxin and corazol injection but exerts no influence on the strichnine-induced seizures. The analogous DSIP injection causes the antiepileptic action in rats kindled through picrotoxin injections. The DSIP intranigral anticonvulsant action is blocked by naloxon and enhanced by haloperidol and yohimbin.

[Effects of neurotropin on seizure activity in picrotoxin kindling].

It is shown that both intracerebral and intraperitoneal neurotropin administration resulted in a decrease of seizure susceptibility of preliminary picrotoxin--kindled rats. On the other hand, neurotropin did not change the course of kindling development. Under conditions of acute picrotoxin--induced seizures it was observed that preliminary cycloheximide (protein-synthesis blocker) administration abolished anticonvulsant properties of neurotropin.