CYP3A5 genotyping for assessing the efficacy of treatment with simvastatin and atorvastatin.

In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simvastatin (n = 175) daily. Genotyping for CYP3A5 was done by PCR-RFLP analysis.

Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index.

Objective: In the present study, we evaluated the influence of lipoprotein lipase (LPL) and apolipoprotein (apo) E polymorphisms on lipid concentrations of 178 Greek men of similar age with coronary heart disease (CHD), but varying body mass index (BMI).

Design: Patients were divided according to their BMI (in kg/m²) into three groups: lean (BMI = 20-24.9), overweight (BMI = 25-29.

Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin.

Background: One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor).

Methods: Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at least 6 months and were genotyped for the CYP3A5 polymorphism.

The Windkessel model revisited: a qualitative analysis of the circulatory system.

In this paper, we derive a comprehensive computational model to estimate the arterial pressure and the cardiac output of humans, by refining and adapting the well-established equations of the Windkessel theory. The model inputs are based on patient specific factors such as age, sex, smoking and fitness habits as well as the use of specific drugs. The model's outputs correlate very strongly with physiological observations, with a low error of approximately 5% for the arterial pressure.

Tissue Doppler imaging analysis at pre-cardioversion time predicts recurrent atrial fibrillation: a 12-month follow-up study.

Introduction: Tissue Doppler imaging (TDI) has been extensively used in several clinical settings. We aimed to investigate whether TDI can predict recurrent atrial fibrillation (AF).

Methods And Results: Seventy-four consecutive patients (aged 62.