Publications by authors named "Vassiliki N Tzelepi"
Background: Lung cancer is the most lethal type of cancer in humans. Cell cycle alterations have commonly been encountered in lung cancer and may have prognostic value.
Materials And Methods: This study investigates the immunohistochemical expression of the important cell cycle regulators phosphatase and tensin homolog deleted on chromosome 10 (PTEN), p27, Cks1, and Skp2 in 128 non-small cell lung carcinomas (64 adenocarcinomas, 46 squamous cell carcinomas, and 18 large cell undifferentiated carcinomas) and adjacent non-neoplastic lung tissue.
Article Synopsis
- The study focuses on the expression of tight junction proteins (occludin and claudins) in various types of thyroid tumors, revealing changes in their expression levels that may relate to cancer progression.
- Both occludin and claudins (1, 4, and 7) showed variable expression across different thyroid neoplasms, with occludin prominently found in vesicles and claudins primarily in membranes.
- Notably, lower claudin-1 expression was linked to poorer disease-free survival, highlighting the potential significance of these proteins in thyroid carcinogenesis and their role in tumor differentiation.