Publications by authors named "Vassiliki G Costa"
Mammillary Bodies in Alzheimer's Disease: A Golgi and Electron Microscope Study.
Am J Alzheimers Dis Other Demen
May 2016
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by irreversible memory decline, concerning no rarely spatial memory and orientation, alterations of the mood and personality, gradual loss of motor skills, and substantial loss of capacities obtained by previous long education. We attempted to describe the morphological findings of the mammillary bodies in early cases of AD. Samples were processed for electron microscopy and silver impregnation techniques.
View Article and Find Full Text PDFThe hypothalamus in Alzheimer's disease: a Golgi and electron microscope study.
Am J Alzheimers Dis Other Demen
August 2015
Article Synopsis
- Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive functions, emotional changes, and motor skill loss, affecting the autonomic nervous system and circadian rhythms.
- The study focused on the morphological changes in the hypothalamus during the early stages of AD, examining specific nuclei such as the suprachiasmatic nucleus, supraoptic nucleus, and paraventricular nucleus.
- Findings revealed a significant decrease in neuronal populations, abnormal axons, and alterations in mitochondrial structures, suggesting these changes may influence circadian rhythm and autonomic regulation in AD patients.
The aim of this study was to evaluate the levels of anti-GM1 in demented patients, correlating them with the type and severity of dementia as well as with the eventually coexistent polyneuropathy. Anti-GM1 concentrations were measured in the sera of 33 demented patients with a male-to-female ratio of 1:2.7 (the mean age was 69.
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