A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer.

Vascular endothelial growth factor promotes angiogenesis, an important mediator of growth and metastasis in human breast cancer. Bevacizumab, a monoclonal antibody to vascular endothelial growth factor, is under investigation as an anti-angiogenic agent. This phase I/II trial evaluated the safety and efficacy of bevacizumab in patients with previously treated metastatic breast cancer.

Localisation of the first-order neurone of the jaw opening reflex elicited by periodontal stimulation.

The localisation of the first-order neurone of the jaw-opening reflex (JOR), provoked by periodontal stimulation, was investigated in the rat. A section of the mandibular part of the trigeminal ganglion was carried out without impairing the motor root. It suppressed the reflex triggered by the stimulation of the lower incisor.

Effects, in the rat, of various stressing procedures on the jaw-opening reflex induced by tooth-pulp stimulation.

Jaw-opening reflex (JOR) induced by a repetitive tooth-pulp stimulation delivered at 1 Hz was observed in awake, freely-moving rats. Modifications of the reflex responses of the digastric muscle were produced by foot-shock stimulation, by an oesophageal administration of placebo and a subcutaneous injection of saline. Subcutaneous injection of saline evoked a total disappearance of the reflex which returned within 30 s.

Variations of the jaw opening reflex observed in awake, freely moving rats.

Long term variations of the jaw opening reflex (J.O.R.