Identification of Highly Potent α-Glucosidase Inhibitors from Artocarpus integer and Molecular Docking Studies.

A new natural Diels-Alder adduct (3) was isolated from the leaves and stem bark of Artocarpus integer, along with seventeen known compounds (1, 2, and 4-18). Structural elucidation was conducted using NMR and HR-ESI-MS data, and comparisons were made with previous studies. Deoxyartonin I (3) exhibited the most potent α-glucosidase inhibition (IC 7.

Manilkzapotane, a novel dimeric alkylresorcinol derivative from the stem bark of .

A novel dimeric alkylresorcinol derivative, manilkzapotane (), along with seven known compounds, lupeol acetate (), lupeol (), arjunolic acid (), ergosterol peroxide (), taraxerol (), hederagonic acid (), and glochidiol () were isolated from the stem bark of . Their structures were determined on the basis of spectroscopic data. DFT-NMR chemical shift calculations and a modified probability (DP4+) method were applied to define the relative configuration of .