Role of anion gap and different electrolytes in hypertension during pregnancy (preeclampsia).

The present study was designed to determine the changes in serum sodium, anion gap, different antioxidants and free radicals in preeclamptic patients and control subjects. Serum sodium, chloride, bicarbonate, calcium, potassium and magnesium were estimated and anion gap was determined in 100 proteinuric hypertensive and 100 normotensive pregnant women. Mean serum sodium, chloride and bicarbonate level (133.

Alterations in gallbladder emptying and bile retention in the absence of changes in bile lithogenicity in postmenopausal women on hormone replacement therapy.

The role of female sex hormones in the pathogenesis of gallstones is well established. Pregnancy, contraceptive use, estrogen replacement therapy in postmenopausal women, and estrogen therapy in men for the treatment of prostatic carcinoma have been found to be associated with increased risk of cholesterol gallstones. Alterations in gallbladder emptying and in bile lithogenicity in postmenopausal women receiving hormone replacement therapy (HRT) have not been studied to date.

Lipid peroxidation and vitamin E status in gestational diabetes mellitus.

Aim: To investigate any correlation between plasma levels of lipid peroxides, antioxidant nutrient (alpha-tocopherol) and oxidized high-density lipoprotein (HDL) in patients with gestational diabetes and those with a normal pregnancy and the incidence of pre-eclampsia.

Methods: Sixty pregnant women attending an antenatal clinic were recruited for the study and were divided into two groups. Thirty women with gestational diabetes mellitus were recruited in the study group.

Maternal and perinatal outcome in rheumatic heart disease.

Objectives: To study the maternal and perinatal outcome of pregnancies complicated by rheumatic heart disease.

Methods: A retrospective study was carried out in the cardio-obstetric clinic of the Postgraduate Institute of Medical Education and Research, Chandigarh (India) over a period of 13 years (1987-1999) involving 486 pregnant patients with rheumatic heart disease. Maternal and perinatal outcome was reviewed.

Pregnancy with acute intermittent porphyria: a case report and review of literature.

Acute intermittent porphyria (AIP) is an inherited disorder characterized by partial defects in the heme biosynthetic pathway. Although its association with pregnancy is rare, it presents the obstetrician with challenging problems especially in labor management, as one of the obstetrical life line drugs (methergin) is contraindicated for use in these patients. We hereby present a case of AIP who had an uneventful pregnancy with a good neonatal outcome.

Metastatic placental site trophoblastic tumor: a case report.

Placental site trophoblastic tumor (PSTT) is very rare. It is an unusual variant of gestational trophoblastic neoplasia usually confined to the uterus, although 10% of patients have metastases. The clinical behaviour of PSTT varies and despite knowledge of its histology, diagnosis of this rare form of trophoblastic disease and prediction of its biological behaviour remains difficult due to only a few cases reported in literature.

Maternal mortality associated with eclampsia and severe preeclampsia of pregnancy.

Objective: To analyse factors associated with maternal mortality in eclampsia and preeclampsia.

Method: Retrospective analysis of 69 maternal deaths due to (eclampsia-61; severe preeclampsia-8) was carried out during a period of 17 years (1982-1998). Maternal condition on admission, associated complications and principal cause of death was analysed in each case.

Non-cirrhotic portal hypertension in pregnancy.

Objective: To study the outcome of pregnancy in women with non-cirrhotic portal hypertension (NCPH).

Method: A retrospective analysis of 50 pregnancies in 27 women with NCPH was carried out. Pregnancy outcome was compared in extra hepatic portal vein obstruction (EHPVO) and non-cirrhotic portal fibrosis (NCPF).

Outcome of pregnancy in Takayasu arteritis.

Of 124 patients with Takayasu arteritis studied over a period of 20 years (1979-1999), 12 female patients experienced 24 pregnancies. The mean age was 23.6+/-3.

Neurological complications of eclampsia.

Objective: A prospective study was conducted to evaluate the various neurological (clinical, radiological and EEG) complications in patients of eclampsia.

Methods: Thirty nine patients of eclampsia were studied regarding neurological findings at presentation and electroencephalographic (EEG) tracings were recorded in each patient. Patients with an abnormal neurologic examination and/or focal or lateralizing findings on EEG, underwent a CT scan (n = 18).

Pregnancy and cirrhosis of the liver.

Pregnancy in patients with cirrhosis of the liver is uncommon. We reviewed 9 pregnancies in 7 patients with cirrhosis. One patient conceived within 1 month of diagnosis and in another the disease was diagnosed during the index pregnancy.

Estimation of oxidative products of nitric oxide (nitrates, nitrites) in preeclampsia.

Oxidative products of nitric oxide, serum nitrates and nitrites were estimated in 50 primigravidas with preeclampsia and in 50 gestation and age-matched normotensive primigravidas. Thirty three (66%) of these women had mild preeclampsia and 17 (34%) had severe preeclampsia. Serum nitrate and nitrite levels were significantly higher in preeclamptic women (nitrates - 15 +/- 1.

Calcium metabolism in pre-eclampsia.

Objectives: To study calcium metabolism in pre-eclampsia and normotensive gravid women.

Method: Ten milliliters of heparinized blood samples and 24-h urine samples were collected from 50 pre-eclamptic and 50 normotensive primigravidae. Blood samples were studied for calcium uptake, intracellular calcium level and calcium-dependent adenosine triphosphatase activity of red blood cell ghost.

Efficacy of magnesium sulphate and phenytoin in the management of eclampsia.

Fifty pregnant women admitted with diagnosis of eclampsia were randomly allocated to magnesium sulphate (Group A) or phenytoin sodium (Group B) treatment group. Incidence of recurrence of seizures maternal as well as perinatal morbidity and mortality were compared in both the groups. Mean maternal age, parity and gestational age was similar in both the groups.

Obstetrical outcomes among women with extrapulmonary tuberculosis.

Background: The prevalence of tuberculosis, especially extrapulmonary tuberculosis, is increasing worldwide. Because information on the outcome of pregnancy among women with extrapulmonary tuberculosis is limited, we studied the course of pregnancy and labor and the perinatal outcome in these women and their infants.

Methods: From 1983 to 1993, we followed 33 pregnant women who had extrapulmonary tuberculosis (12 with tuberculous lymphadenitis and 9 with intestinal, 7 with skeletal, 2 with renal, 2 with meningeal, and 1 with endometrial tuberculosis) through their deliveries.

Pregnancy following cardiac valve replacement surgery.

Objectives: To study the outcome of pregnancy in women with artificial heart valves and to compare the maternal and perinatal outcome in mechanical and bioprosthetic valves.

Method: Retrospective analysis of 34 pregnancies in 29 women who conceived after cardiac valve replacement was carried out.

Results: The majority of women (76.

Effect of maternal low dose aspirin on neonatal platelet function.

Objective: To evaluate the effect of maternal low dose aspirin ingestion in platelet function of newborn.

Design: Prospective randomized placebo controlled study.

Methods: 25 neonates born to mothers receiving low dose aspirin and 25 matched neonates with no maternal exposure to aspirin were studied.

Pregnancy in patients with systemic lupus erythematosus.

We reviewed the obstetrical performance and outcome of 15 pregnancies in patients with systemic lupus erythematosus (SLE) (study group) and compared them with 45 age and parity-matched normal pregnancies (control group). Eleven women (73.8%) were in remission phase and 4 (26.

Histopathological study of placental bed biopsy in placenta previa.

Background: To study placental bed biopsy changes in placenta previa and normally implanted placenta.

Subject And Method: Fifty placental bed biopsies from 50 patients with placenta previa and 50 placental bed biopsies from normally implanted placenta were taken at cesarean section. Placental bed biopsy was stained with hematoxyline and eosin for histological examination.

Comparison of lytic cocktail and magnesium sulphate regimens in eclampsia: a retrospective analysis.

Retrospective analysis of eclamptic patients was done during two time periods. In time period A (Jan. 1987-Dec.