Publications by authors named "Vasiliy V Spiridonov"
In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering.
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- A new method for creating mixed polymer micelles using amorphous poly-D,L-lactide-block-polyethyleneglycol and crystalline amino-terminated poly-L-lactide significantly reduces the preparation time from several days to just 15-20 minutes through ultrasonication.
- The resulting micelles, approximately 150 nm in size, exhibit low cytotoxicity, high stability in various conditions, and have an average molecular weight of 2.1 × 10 with an aggregation number of 6000.
- They show potential as drug delivery vehicles, effectively encapsulating the antitumor drug paclitaxel with a lethal concentration similar to that found in commercial formulations.