Publications by authors named "Vasiliy Kaleda"
The Effect of Untreated Illness in Youth Depression: A Cross-Sectional Study.
Consort Psychiatr
December 2022
Background: The existing research has mainly focused on exploring how the duration of untreated psychosis effects the further course of the disease. By contrast, the duration of an untreated illness (DUI) in youth depression and its impact on the further course of the disease has remained scarcely investigated.
Aim: The current study aims to determine how the duration of untreated illness affects the severity of the symptoms during the first depressive episode and the degree to which the symptoms are reduced after treatment.
Article Synopsis
- The study examines the differences in the morphology of the human cerebral cortex across various psychiatric disorders, suggesting that early growth patterns in the cortex may influence later variations in surface area and mental health outcomes.
- Using data from over 27,000 MRI scans, researchers identified significant differences in cortical area among individuals with conditions like ADHD, schizophrenia, and major depression, particularly in association cortices linked to cognitive processing.
- The findings indicate a correlation between these structural differences and prenatal gene expression related to cell types important for brain development, highlighting how prenatal factors may play a crucial role in the risk of developing mental illnesses.
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.
View Article and Find Full Text PDFAlterations in white matter microstructure and cortical thickness in individuals at ultra-high risk of psychosis: A multimodal tractography and surface-based morphometry study.
Psychiatry Res Neuroimaging
July 2019
Article Synopsis
- The study investigates differences in white and grey matter structures in young males at ultra-high risk of psychosis compared to healthy controls using advanced imaging techniques.* -
- Findings revealed increased radial diffusivity in certain white matter tracts and reduced cortical thickness in various brain regions among UHR subjects, suggesting potential structural abnormalities.* -
- The researchers concluded that these alterations in brain connectivity and anatomy may contribute to the cognitive and social functioning deficits observed in individuals at risk for developing psychosis.*
The study aimed to confirm the association of the schizophrenia genome-wide association study (GWAS) hit rs2514218 located near the DRD2 gene with the risk of the disease and to investigate the relationships between rs2514218 and schizophrenia-related clinical and neuroimaging phenotypes. Genotypes at the rs2514218 site were determined for 2148 schizophrenia spectrum patients and 1273 control subjects from the Russian population. In subsets of subjects, we assessed symptomatic dimensions using the Positive and Negative Syndrome Scale (n = 1651) and Temporal Experience of Pleasure Scale (n = 471).
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