Publications by authors named "Vasiliy I Pustovoyt"
Traumatic brain injury (TBI) is one of the leading causes of mortality and disability among young and middle-aged individuals. Adequate and timely diagnosis of primary brain injuries, as well as the prompt prevention and treatment of secondary injury mechanisms, significantly determine the potential for reducing mortality and severe disabling consequences. Therefore, it is crucial to have objective markers that indicate the severity of the injury.
View Article and Find Full Text PDFArticle Synopsis
- Proteomic and metabolomic research helps analyze the molecular profiles of athletes, particularly during aerobic activities like running at high altitudes.
- Changes in specific metabolites, such as 4-hydroxyproline and methionine, were observed during recovery, indicating metabolic shifts.
- Proteomic analysis showed variations in protein expression related to immune function, muscle damage, and athlete performance, suggesting a need for further studies on metabolic models to track training intensity and adaptation.
Background: Tracking the migration pathways of living cells after their introduction into a patient's body is a topical issue in the field of cell therapy. Questions related to studying the possibility of long-term intravital biodistribution of mesenchymal stromal cells in the body currently remain open.
Methods: Forty-nine laboratory animals were used in the study.
The aim of this study was to determine the influence of high-intensity training under extreme conditions (T = 40 °C) on the metabolism and immunological reactions of athletes. Male triathletes ( = 11) with a high level of sports training performed load testing to failure (17 ± 2.7 min) and maximum oxygen consumption (64.
View Article and Find Full Text PDFNeuroplasticity and inflammation play important part in the body's adaptive reactions in response to prolonged physical activity. These processes are associated with the cross-interaction of the nervous and immune systems, which is realized through the transmission of signals from neurotransmitters and cytokines. Using the methods of flow cytometry and advanced biochemical analysis of blood humoral parameters, we showed that intense and prolonged physical activity at the anaerobic threshold, without nutritional and metabolic support, contributes to the development of exercise-induced immunosuppression in sportsmen.
View Article and Find Full Text PDFArticle Synopsis
- * A study of 3,661 healthy athletes used various medical examinations and machine learning to analyze health indicators related to recovery post-competition.
- * Key findings indicated that muscle metabolism parameters (like aspartate aminotransferase and creatine kinase) and ornithine cycle parameters (like creatinine and urea) were crucial for distinguishing between catabolic and anabolic metabolism in athletes.