New remains of a Taymyr mammoth, including bones, bone collagen, hairs, skin, and soft (muscle and fat) tissues were studied comprehensively by mineralogical, spectroscopic, chromatographic, and isotope-geochemical methods. The results were used to infer the mammoth's biological age and diet, paleoclimatic conditions, and the mechanisms and degree of fossilization of the remains.
View Article and Find Full Text PDFThis work is mostly devoted to the search for effective solutions to the problem of early diagnosis of plant stress (given an example of wheat and its drought stress), which would be based on explainable artificial intelligence (XAI). The main idea is to combine the benefits of two of the most popular agricultural data sources, hyperspectral images (HSI) and thermal infrared images (TIR), in a single XAI model. Our own dataset of a 25-day experiment was used, which was created via both (1) an HSI camera Specim IQ (400-1000 nm, 204, 512 × 512) and (2) a TIR camera Testo 885-2 (320 × 240, res.
View Article and Find Full Text PDFThis article is devoted to searching for high-level explainable features that can remain explainable for a wide class of objects or phenomena and become an integral part of explainable AI (XAI). The present study involved a 25-day experiment on early diagnosis of wheat stress using drought stress as an example. The state of the plants was periodically monitored via thermal infrared (TIR) and hyperspectral image (HSI) cameras.
View Article and Find Full Text PDFAbnormal mRNAs of the hybrid BCR-ABL gene in the majority of cases initiate the synthesis of proteins with a mass of 210 kDa (p210), 190 kDa (p190), and 230 kDa (p230). Expression of the p210 variant is most common in CML (95% of cases), while the p190 and p230 variants are less common (1-4%). On the contrary, p190 predominates in ALL.
View Article and Find Full Text PDFGonadotropin-dependent precocious puberty (central) is a condition resulting from the early (up to 8 years in girls and 9 years in boys) reactivation of the hypothalamic-pituitary-gonadal axis. An increase in the secretion of sex steroids by the gonads in this form is a consequence of the stimulation of the sex glands by gonadotropic hormones of the pituitary gland. In the absence of central nervous system abnormalities, CPP is classified as idiopathic and as familial in some cases, emphasizing the genetic origin of this disorder.
View Article and Find Full Text PDFSomatic mutations associated with oncological diseases, including Ph-myeloproliferative neoplasms (Ph-MPN), are very diverse, occur with different frequencies and different allelic burden levels. Therefore, at the initial stage of performing molecular-genetic diagnostic procedures, it is desirable to be able to conduct screening tests in the laboratory. This is especially important when analyzing rare and diverse mutations.
View Article and Find Full Text PDFProbl Endokrinol (Mosk)
December 2019
Androgen insensitivity syndrome is an X-linked disorder characterized by either complete or partial insensitivity of target tissues to androgens. This disease is caused by mutations in the AR gene located on the Х chromosome. Currently, there are no distinct clinical, biochemical, or hormonal markers that would allow one to differentiate androgen insensitivity syndrome from a number of other forms of 46,XY disorders of sex development.
View Article and Find Full Text PDFThe kinetics of the reaction between fluorine atoms and pentafluoropropionic acid has been studied experimentally at T = 262-343 K. The overall reaction rate constant decreases with temperature: k1(T) = 6.1 × 10(-13) exp(+1166 K)/T) cm(3) molecule(-1) s(-1).
View Article and Find Full Text PDFThe uptake of ClO radicals on KBr, NaCl, and NaBr dry solid films was studied at 1 Torr pressure of helium over the temperature range 290-350 K using a flow tube technique with a modulated molecular beam mass spectrometer as the detection method. A Pyrex tube with the deposited salt sample was introduced into the flow reactor along its axis. The ClO uptake coefficient on the KBr surface did not depend on temperature within the experimental accuracy of ∼20%.
View Article and Find Full Text PDF