Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of viruses and species.

Infections with viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a fatal outcome if left untreated. Diseases caused by tropical parasites of the species, and , constitute significant socioeconomic burden in sub-Saharan Africa and continental Latin America, yet drug development is under-funded.