Comparison of Ga-PSMA PET/CT with fluoride PET/CT for detection of bone metastatic disease in prostate cancer.

Background: F-NaF positron emission tomography/computed tomography (fluoride PET/CT) is considered the most sensitive technique to detect bone metastasis in prostate cancer (PCa). Ga-PSMA-11 (PSMA) PET/CT is increasingly used for staging of PCa. This study primarily aimed to compare the diagnostic performance of fluoride PET/CT and gallium-based PSMA PET/CT in identifying bone metastasis followed by a comparison of PSMA PET/CT with contrast-enhanced CT (CE-CT) in identifying soft tissue lesions as a secondary objective.

Comparison of Ga-PSMA-11 PET/CT with C-acetate PET/CT in re-staging of prostate cancer relapse.

Positron emission tomography (PET) imaging is used to localize recurrent disease in prostate cancer (PCa). The tracer Ga-PSMA-11 visualizes lesions overexpressing prostate-specific membrane antigen (PSMA), while C-acetate visualizes lesions with increased anabolic metabolism. The aim of this study was to compare the performance of PSMA-PET and acetate-PET in re-staging patients with biochemical relapse.