Publications by authors named "Vasile Palade"

Metabolic engineering is a rapidly evolving field that involves optimizing microbial cell factories to overproduce various industrial products. To achieve this, several tools, leveraging constraint-based stoichiometric models and metaheuristic algorithms like particle swarm optimization (PSO), have been developed. However, PSO can potentially get trapped in local optima.

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Objective: This paper aims to address the challenges in abstract screening within systematic reviews (SR) by leveraging the zero-shot capabilities of large language models (LLMs).

Methods: We employ LLM to prioritize candidate studies by aligning abstracts with the selection criteria outlined in an SR protocol. Abstract screening was transformed into a novel question-answering (QA) framework, treating each selection criterion as a question addressed by LLM.

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Premature convergence is a thorny problem for particle swarm optimization (PSO) algorithms, especially on multimodal problems, where maintaining swarm diversity is crucial. However, most enhancement strategies for PSO, including the existing diversity-guided strategies, have not fully addressed this issue. This paper proposes the virtual position guided (VPG) strategy for PSO algorithms.

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Research evidence shows that physical rehabilitation exercises prescribed by medical experts can assist in restoring physical function, improving life quality, and promoting independence for physically disabled individuals. In response to the absence of immediate expert feedback on performed actions, developing a Human Action Evaluation (HAE) system emerges as a valuable automated solution, addressing the need for accurate assessment of exercises and guidance during physical rehabilitation. Previous HAE systems developed for the rehabilitation exercises have focused on developing models that utilize skeleton data as input to compute a quality score for each action performed by the patient.

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The multi-view data clustering has attracted much interest from researchers, and the large-scale multi-view clustering has many important applications and significant research value. In this article, we fully make use of the consensus and complementary information, and exploit a bipartite graph to depict the duality relationship between original points and anchor points. To be specific, representative anchor points are selected for each view to construct corresponding anchor representation matrices, and all views' anchor points are utilized to construct a common representation matrix.

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The goal of textual adversarial attack methods is to replace some words in an input text in order to make the victim model misbehave. This article proposes an effective word-level adversarial attack method based on sememes and an improved quantum-behaved particle swarm optimization (QPSO) algorithm. The sememe-based substitute method, which uses the words sharing the same sememes as the substitutes of the original words, is first employed to form the reduced search space.

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Performing prescribed physical exercises during home-based rehabilitation programs plays an important role in regaining muscle strength and improving balance for people with different physical disabilities. However, patients attending these programs are not able to assess their action performance in the absence of a medical expert. Recently, vision-based sensors have been deployed in the activity monitoring domain.

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AutoDock is a widely used software for flexible ligand docking problems since it is open source and easy to be implemented. In this paper, a novel hybrid algorithm is proposed and applied in the docking environment of AutoDock version 4.2.

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With the development of autonomous vehicles, localization and mapping technologies have become crucial to equip the vehicle with the appropriate knowledge for its operation. In this paper, we extend our previous work by prepossessing a localization and mapping architecture for autonomous vehicles that do not rely on GPS, particularly in environments such as tunnels, under bridges, urban canyons, and dense tree canopies. The proposed approach is of two parts.

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Background: A high-quality docking method tends to yield multifold gains with half pains for the new drug development. Over the past few decades, great efforts have been made for the development of novel docking programs with great efficiency and intriguing accuracy. AutoDock Vina (Vina) is one of these achievements with improved speed and accuracy compared to AutoDock4.

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Protein-ligand docking is of great importance to drug design, since it can predict the binding affinity between ligand and protein, and guide the synthesis direction of the lead compounds. Over the past few decades, various docking programs have been developed, some of them employing novel optimization algorithms. However, most of those methods cannot simultaneously achieve both good efficiency and accuracy.

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This paper investigates the problem of false data injection attack (FDIA) detection in microgrids. The grid under study is a DC microgrid with distributed boost converters, where the false data are injected into the voltage data so as to investigate the effect of attacks. The proposed algorithm uses a bank of sliding mode observers that estimates the states of the neighbor agents.

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Brain tumors are a pernicious cancer with one of the lowest five-year survival rates. Neurologists often use magnetic resonance imaging (MRI) to diagnose the type of brain tumor. Automated computer-assisted tools can help them speed up the diagnosis process and reduce the burden on the health care systems.

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Deep learning has gained immense attention from researchers in medicine, especially in medical imaging. The main bottleneck is the unavailability of sufficiently large medical datasets required for the good performance of deep learning models. This paper proposes a new framework consisting of one variational autoencoder (VAE), two generative adversarial networks, and one auxiliary classifier to artificially generate realistic-looking skin lesion images and improve classification performance.

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Autonomous Vehicles (AVs) have the potential to solve many traffic problems, such as accidents, congestion and pollution. However, there are still challenges to overcome, for instance, AVs need to accurately perceive their environment to safely navigate in busy urban scenarios. The aim of this paper is to review recent articles on computer vision techniques that can be used to build an AV perception system.

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Many advanced driver assistance systems (ADAS) are currently trying to utilise multi-sensor architectures, where the driver assistance algorithm receives data from a multitude of sensors. As mono-sensor systems cannot provide reliable and consistent readings under all circumstances because of errors and other limitations, fusing data from multiple sensors ensures that the environmental parameters are perceived correctly and reliably for most scenarios, thereby substantially improving the reliability of the multi-sensor-based automotive systems. This paper first highlights the significance of efficiently fusing data from multiple sensors in ADAS features.

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In general, flexible ligand docking is used for docking simulations under the premise that the position of the binding site is already known, and meanwhile it can also be used without prior knowledge of the binding site. However, most of the optimization search algorithms used in popular docking software are far from being ideal in the first case, and they can hardly be directly utilized for the latter case due to the relatively large search area. In order to design an algorithm that can flexibly adapt to different sizes of the search area, we propose an effective swarm intelligence optimization algorithm in this paper, called diversity-controlled Lamarckian quantum particle swarm optimization (DCL-QPSO).

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This paper presents a novel diagnostic framework for distributed power systems that is based on using generative adversarial networks for generating artificial knockoffs in the power grid. The proposed framework makes use of the raw data measurements including voltage, frequency, and phase-angle that are collected from each bus in the cyber-physical power systems. The collected measurements are firstly fed into a feature selection module, where multiple state-of-the-art techniques have been used to extract the most informative features from the initial set of available features.

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Low-cost Inertial Navigation Sensors (INS) can be exploited for a reliable solution for tracking autonomous vehicles in the absence of GPS signals. However, position errors grow exponentially over time due to noises in the sensor measurements. The lack of a public and robust benchmark dataset has however hindered the advancement in the research, comparison and adoption of recent machine learning techniques such as deep learning techniques to learn the error in the INS for a more accurate positioning of the vehicle.

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Autodock and its various variants are widely utilized docking approaches, which adopt optimization methods as search algorithms for flexible ligand docking and virtual screening. However, many of them have their limitations, such as poor accuracy for dockings with highly flexible ligands and low docking efficiency. In this paper, a multi-swarm optimization algorithm integrated with Autodock environment is proposed to design a high-performance and high-efficiency docking program, namely, MSLDOCK.

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Background: Protein-ligand docking has emerged as a particularly important tool in drug design and development, and flexible ligand docking is a widely used method for docking simulations. Many docking software packages can simulate flexible ligand docking, and among them, Autodock is widely used. Focusing on the search algorithm used in Autodock, many new optimization approaches have been proposed over the last few decades.

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Digital retinal imaging is a challenging screening method for which effective, robust and cost-effective approaches are still to be developed. Regular screening for diabetic retinopathy and diabetic maculopathy diseases is necessary in order to identify the group at risk of visual impairment. This paper presents a novel automatic detection of diabetic retinopathy and maculopathy in eye fundus images by employing fuzzy image processing techniques.

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Background: Finding an efficient method to solve the parameter estimation problem (inverse problem) for nonlinear biochemical dynamical systems could help promote the functional understanding at the system level for signalling pathways. The problem is stated as a data-driven nonlinear regression problem, which is converted into a nonlinear programming problem with many nonlinear differential and algebraic constraints. Due to the typical ill conditioning and multimodality nature of the problem, it is in general difficult for gradient-based local optimization methods to obtain satisfactory solutions.

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Hidden Markov Models (HMMs) are powerful tools for multiple sequence alignment (MSA), which is known to be an NP-complete and important problem in bioinformatics. Learning HMMs is a difficult task, and many meta-heuristic methods, including particle swarm optimization (PSO), have been used for that. In this paper, a new variant of PSO, called the random drift particle swarm optimization (RDPSO) algorithm, is proposed to be used for HMM learning tasks in MSA problems.

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