Macrolactin A Is an Inhibitor of Protein Biosynthesis in Bacteria.

Macrolactin A (McA) is a secondary metabolite produced by Bacillus species. It has been known for its antimicrobial properties since the late 1980s, although the exact mechanism of its antibacterial activity remains unknown. In this study, we have found that McA is an inhibitor of protein synthesis in bacteria.

Synthesis, Structure and Biological Activity of 2-Methyl-5-nitro-6-phenylnicotinohydrazide-Based Hydrazones.

The synthetic availability and wide range of biological activity of hydrazides and hydrazones make them attractive subjects for investigation. In this study, we focused on synthesis of 2-methyl-5-nitro-6-phenylnicotinohydrazide-based hydrazones derived from the corresponding substituted aldehydes. The structure of the obtained compounds was studied using NMR spectroscopy and DFT calculations.

Flavuside B exhibits antioxidant and anti-inflammatory properties in Staphylococcus aureus infected skin wound and affect the expression of genes controlling bacterial quorum sensing.

Aims: The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of marine fungal cerebroside flavuside B (FlaB) on Staphylococcus aureus-infected keratinocytes in in vitro skin wounds and to identify FlaB targets in bacterial and human cells.

Methods And Results: A combination of enzyme-linked immunosorbent assay (ELISA), plate spectrofluorimetry, and flow cytometry with fluorescence dye staining, scratch assay, and real-time cell imaging techniques was used to investigate the effects of FlaB on S. aureus-infected HaCaT keratinocytes.

Anisotropy in Carbon Dioxide Adsorption on Forsterite.

In this study, density functional theory (DFT) method were used to investigate the adsorption behavior and binding mechanism of CO molecules on six crystallographic surfaces of forsterite (MgSiO). The influence of surface crystallographic orientation on CO adsorption efficiency was examined at the atomic level. Results showed stable binding of CO on all surfaces.

Effect of Waste Concrete Powder Content and Microwave Heating Parameters on the Properties of Porous Alkali-Activated Materials from Coal Gangue.

The objective of this research is to fabricate waste-based alkali-activated foams with better properties in a quick time by using energy-efficient techniques such as microwave irradiation. The present study reports the effect of microwave heating parameters, including heating time and output power, on the properties of porous alkali-activated materials (AAMs) that use coal gangue (CG) as a precursor. The effects of concrete waste (CW) content (0-20 wt %) on the performance and microstructure of CG-based AAMs were investigated.

The Ecological Strategy Determines the Response of Fungi to Stress: A Study of the 2,4-diacetylphloroglucinol Activity Against Aspergillus and Fusarium Species.

Aspergillus and Fusarium are two economically important genera of fungi. They cause significant yield losses and contamination of crops with mycotoxins. In this study we aimed to evaluate the impact of 2,4-diacetylphloroglucinol (2,4-DAPG) on Aspergillus and Fusarium fungi.

Subinhibitory effects of 2,4-diacetylphloroglucinol on filamentous fungus Aspergillus fumigatus.

Aims: Aspergillus fungi are common members of the soil microbiota. Some physiological and structural characteristics of Aspergillus species make them important participants in soil ecological processes. In this study, we aimed to evaluate the impact of 2,4-diacetylphloroglucinol (2,4-DAPG), a common metabolite of soil and rhizosphere bacteria, on the physiology of Aspergillus fumigatus.

Mechanism of Cs Immobilization within a Sodalite Framework: The Role of Alkaline Cations and the Si/Al Ratio.

Conditioning of radioactive waste generated from the operation of medical institutions, nuclear cycle facilities, and nuclear facilities is important for the safety of the environment. One of the most hazardous radionuclides is radioactive cesium. There is a need for more effective solutions to contain radionuclides, especially cesium (Cs+).

Exploring the antibacterial action of gliotoxin: Does it induce oxidative stress or protein damage?

The study aimed to investigate the effects of gliotoxin (GTX), a secondary fungal metabolite belonging to the epipolythiodioxopiperazines class, on Gram-positive and Gram-negative bacteria. While the cytotoxic mechanism of GTX on eukaryotes is well understood, its interaction with bacteria is not yet fully comprehended. The study discovered that S.

Gausemycin A-Resistant Demonstrates Affected Cell Membrane and Cell Wall Homeostasis.

Antibiotic resistance is a significant and pressing issue in the medical field, as numerous strains of infectious bacteria have become resistant to commonly prescribed antibiotics. is a bacterium that poses a grave threat, as it is responsible for a large number of nosocomial infections and has high mortality rates worldwide. Gausemycin A is a new lipoglycopeptide antibiotic that has considerable efficacy against multidrug-resistant strains.

Spatial Ecology of Siberian Forest Reindeer (Rangifer tarandus valentinae Flerov, 1932) of Kuznetsk Alatau.

For the first time, information is provided on the size of the home range of Siberian forest reindeer (Rangifer tarandus valentinae) of the Altai-Sayan population of Kuznetsk Alatau, the minimum distance that the deer passes per day, their changes, and changes of habitats during the annual cycle. Possible reasons for the cyclical use of the habitat by forest reindeer are discussed.

Triazoles and Strobilurin Mixture Affects Soil Microbial Community and Incidences of Wheat Diseases.

Pesticides are widely used in agriculture as a pest control strategy. Despite the benefits of pesticides on crop yields, the persistence of chemical residues in soil has an unintended impact on non-targeted microorganisms. In the present study, we evaluated the potential adverse effects of a mixture of fungicides (difenoconazole, epoxiconazole, and kresoxim-methyl) on soil fungal and bacterial communities, as well as the manifestation of wheat diseases.

Complete Genome Sequences of Streptomyces albus Strain INA 01303.

Here, we report the complete genome sequence of Streptomyces albus strain INA 01303, which was isolated from the Salt Lake Tambukan (Russia). The genome consists of a linear 6,840,896-nucleotide chromosome. This strain is predicted to produce a range of novel secondary metabolites with antibiotic activity.

2,4-Diacetylphloroglucinol Modulates Virulence.

The dimorphic fungus is one of the most important opportunistic pathogens for humankind. The use of fungicides against could be associated with sub-inhibitory effects, which are referred to as fungal stress responses and are undesirable for the host. In this work, we investigated the antifungal action of 2,4-diacetylphloroglucinol (2,4-DAPG) against ATCC 10231 with a focus on their biofilm-forming ability.

Draft Genome Sequence of Pseudomonas brassicacearum Strain UTMN3, a Biological Control Agent from the Rhizosphere of Pisum sativum.

Here, we announce and describe the draft genome sequence of Pseudomonas brassicacearum UTMN3, which contains 40 contigs comprising 6,658,810 bp, with a GC content of 60.9%. The genome contains 5,825 protein-coding genes and 65 RNA-coding genes.

Genome Analysis of the Probiotic Strain Enterococcus faecium Ef79OSAU.

We report here the draft genome sequence of Enterococcus faecium strain Ef79OSAU, which was isolated from swine feces. The characteristics of strain Ef79OSAU reveal the absence of pathogenicity factors, a wide range of antimicrobial activity , and antilisteriosis activity . Analysis of the E.

Is It Possible to Create Antimicrobial Peptides Based on the Amyloidogenic Sequence of Ribosomal S1 Protein of ?

The development and testing of new antimicrobial peptides (AMPs) represent an important milestone toward the development of new antimicrobial drugs that can inhibit the growth of pathogens and multidrug-resistant microorganisms such as Gram-negative bacteria. Most AMPs achieve these goals through mechanisms that disrupt the normal permeability of the cell membrane, which ultimately leads to the death of the pathogenic cell. Here, we developed a unique combination of a membrane penetrating peptide and peptides prone to amyloidogenesis to create hybrid peptide: "cell penetrating peptide + linker + amyloidogenic peptide".

Smart and Sustainable Nanotechnological Solutions in a Battle against COVID-19 and Beyond: A Critical Review.

The variety of available biocidal features make nanomaterials promising for fighting infections. To effectively battle COVID-19, categorized as a pandemic by the World Health Organization (WHO), materials scientists and biotechnologists need to combine their knowledge to develop efficient antiviral nanomaterials. By design, nanostructured materials (spherical, two-dimensional, hybrid) can express a diverse bioactivity and unique combination of specific, nonspecific, and mixed mechanisms of antiviral action.

Stability of electron-hole liquid in quantum wells.

Density functional theory is used to calculate the energy of electron-hole liquid and the equilibrium density of electron-hole pairs in quantum wells. Nonlinear Kohn-Sham equations for electrons and holes are solved numerically. The influence of the depth and width of the quantum well, the ratio of the hole and electron masses, and the spin splitting of the hole band on the properties of electron-hole liquid is studied.

Draft Genome Sequence of the Multiple Antibiotic Producer Bacillus velezensis X-BIO-1.

Here, we describe the draft genome sequence of strain X-BIO-1, which contains 16 contigs, comprising 3,861,135 bp with a G+C content of 46.54%. The annotated draft genome contains 3,710 protein-coding genes and 62 RNA genes.

Genetic Specificity of the Siberian Forest Reindeer (Rangifer tarandus valentinae Flerov, 1932) of the Kuznetsk Alatau.

This is the first study to show the genetic identity of the Altai-Sayan population of the forest reindeer of the Kuznetsk Alatau (Rangifer tarandus valentinae). The population is characterized by the existence of unique mitochondrial lines, the absence of signs of introgression of domestic rein deer mtDNA, as well as a low level of genetic diversity. In the sample studied, only two nucleotide substitutions (both of them transitions) were revealed, the nucleotide diversity (0.