Publications by authors named "Vasil Nanev"

Article Synopsis
  • The study investigates the roles of cleaved caspase-3 and Ki-67 index from diagnostic biopsies in predicting responses to neoadjuvant chemotherapy in breast cancer patients, focusing on different molecular subtypes and tumour characteristics.
  • An analysis of 110 patients revealed significant relationships between Ki-67 levels and factors like tumour grade and molecular subtype, while caspase-3 expression correlated with treatment response according to the Sataloff classification.
  • The findings suggest that while cleaved caspase-3 could indicate better responses to treatment, Ki-67 levels did not significantly differ among patients with varying treatment outcomes, highlighting the potential of these biomarkers in predicting treatment responses and guiding patient management.
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Lymphoepithelioma-like breast carcinoma (LELC) is a rare type of malignant breast tumor that is not included in the current edition of the World Health Organization (WHO) classification of breast tumors. Currently, there are no clearly defined therapeutic strategies, and the general information on breast LELC is based on sporadic clinical cases described in the medical literature. We present a clinical case that describes a 49-year-old woman with a tumor formation in the right breast, histologically verified as LELC, together with a non-palpable, synchronous high-grade invasive ductal carcinoma and ductal carcinoma in situ Grade 2 (DCIS G2) in a different quadrant of the same breast.

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Introduction: Radiotherapy (RT) is a widely used treatment modality of malignant tumours of the uterine cervix and body. There are different techniques to deliver RT to the tumour lesions, including external beam radiation and brachytherapy. All international guidelines recommend RT as treatment modality for many stages of uterine cervical and body cancers because it improves a number of oncological outcomes, such as disease-free and overall survival.

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A 68-year-old female presented to the Gynecologic Oncology Clinic with a right-lower quadrant abdominal mass 3 × 4 cm in diameter palpable on pelvic examination. Her routine laboratory tests were normal. Transvaginal ultrasonography revealed a cystic mass in the right adnexa 3.

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