Biopharmaceutical studies of a novel sedative sublingual lozenge based on glycine and tryptophan: A rationale for mucoadhesive agent selection.

Effective sedative drugs are in great demand due to increasing incidence of nervous disorders. The present work was aimed to develop a novel sublingual sedative drug based on glycine and L-tryptophan amino acids. Carbopol and different hydroxypropyl methylcellulose species were alternatively tested as mucoadhesive agents intended to prolong tryptophan sublingual release time.

Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications.

Stimuli-responsive and tunable soft-matter systems are an advanced class of materials applicable for drug delivery. Liquid crystals (LCs) are promising candidates as multifunctional materials that can respond to temperature, light or magnetic field. Particularly, ordering and physical properties of thermoresponsive LCs depend predominantly on temperature as external trigger.

Findings of new phytoplankton species in the Barents Sea as a consequence of global climate changes.

Over the past few decades, the Earth's climate has been characterized by a stable increase in temperature, which in many regions leads to a change in the composition of flora and fauna. A striking manifestation of this process is the appearance in ecological communities of new, uncharacteristic for them, species of animals and plants. One of the most productive and at the same time the most vulnerable in this respect are the marine ecosystems of the Arctic.