Slit and Robo control the development of dendrites in Drosophila CNS.

The molecular mechanisms that generate dendrites in the CNS are poorly understood. The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone collapse in vivo. However, in cultured neurons, these molecules promote dendritic development.

Gliopodia extend the range of direct glia-neuron communication during the CNS development in Drosophila.

Midline glia are a source of cues for neuronal navigation and differentiation in the Drosophila CNS. Despite their importance, how glia and neurons communicate during the development is not fully understood. Here, we examined dynamic morphology of midline glia and assessed their direct cellular interactions with neurons within the embryonic CNS.

Stress-reactivity of a Drosophila melanogaster strain with impaired juvenile hormone action.

Met(27) is a null allele of the Methoprene-tolerant gene of D. melanogaster that shows resistance to the toxic effects of both juvenile hormone (JH) and a JH analog, methoprene. The mechanism of resistance appears to be altered JH reception.

[The dopamine system stress reaction in adults of Drosophila virilis is controlled by genes of Chromosome 6].

A linkage group of the gene responsible for changes of DA titer under stress in adults of D. virilis was determined. Line 160 of D.

[Some regularities in the genetic control of the stress reaction in Drosophila].

The heat-shock response was studied in Drosophila virilis strains with normal and impaired neurohormonal stress reaction. Flies from the latter strain were shown to have the impaired heat-shock response. In this strain, transcription of the heat shock gene hsp83 is reduced and synthesis of all heat shock proteins is suppressed.

[The heat-shock reaction is disturbed in a Drosophila virilis strain incapable of a neurohormonal stress reaction].

Cellular stress response was investigated in two lines of D. virilis: wild type and line with disturbed neurohormonal stress-reaction. Analysis of proteins, synthesized in salivary glands of larvae of both lines under heat stress, revealed malfunction in heat shock reaction of mutant specimen.

Prolonged negative selection of Drosophila melanogaster for a character of adaptive significance disturbs stress reactivity.

The metabolism of juvenile hormone by JH-esterase and JH-epoxide hydrolase, and octopamine by tyrosine decarboxylase were studied under normal and stress conditions in flies of two related lines of D. melanogaster. One was selected for high (HA line) and another for low (LA line) male sexual activity for more than 700 generations.

[Genes, regulating activity of alkaline phosphatase and tyrosine decarboxylase in Drosophila virilis, linked to chromosome 6].

The linkage group of genes controlling alkaline-phosphatase (AP) and tyrosine-decarboxylase (TDC) activities in Drosophila virilis adults was determined. D. virilis strain 160, with all autosomes marked with recessive morphological mutations, was used for the analysis.

[Genes, controlling the response of the juvenile hormone degradation system to stress in the Drosophila virilis imago, linked to chromosome 6].

Chromosome localization of the gene controlling the stress response of DFP-sensitive juvenile hormone (JH) esterase in females of Drosophila virilis was conducted. Line 160 of D. virilis carrying recessive markers on all chromosomes was used as a tester.

[Selection for sex behavior changes the metabolism of juvenile hormone in Drosophila melanogaster].

The metabolism of juvenile hormone (JH) was studied in two lines of Drosophila melanogaster selected for differences in mating behavior. The lines were tested under normal conditions and after short-term heat shock. Females of the HA line (selected for high male mating activity) were shown to exhibit a high level of JH hydrolyzing activity under normal conditions.