Importance: Acute gastrointestinal variceal hemorrhage is a major cause of morbidity and mortality in cirrhotic liver disease. Approximately one-third of cirrhotic patients will have variceal hemorrhage, and each bleeding episode is associated with up to 20% mortality. Balloon tamponade devices are used to achieve temporary hemostasis of bleeding esophagogastric varices and as a bridge to definitive therapy.
View Article and Find Full Text PDFMixed-phenotype acute leukemia is a rare subtype of leukemia in which both myeloid and lymphoid markers are co-expressed on the same malignant cells. The pathogenesis is largely unknown, and the treatment is challenging. We previously reported the specific association of the recurrent t(8;12)(q13;p13) chromosomal translocation that creates the ETV6-NCOA2 fusion with T/myeloid leukemias.
View Article and Find Full Text PDFJ Am Coll Emerg Physicians Open
August 2021
Transverse myelitis is often clinically indistinguishable from compressive myelopathies that require emergent neurosurgical intervention. Here, we present a case of acute varicella zoster virus transverse myelitis that was associated with a compressive fluid collection on magnetic resonance imaging (MRI) requiring emergent operative intervention. To our knowledge, this is the first reported case of acute transverse myelitis and a compressive cord lesion in the adult population.
View Article and Find Full Text PDFGram-negative bacteria such as Escherichia coli build a peptidoglycan (PG) cell wall in their periplasm using the precursor known as lipid II. Lipid II is a large amphipathic molecule composed of undecaprenyl diphosphate and a disaccharide-pentapeptide that PG-synthesizing enzymes use to build the PG sacculus. During PG biosynthesis, lipid II is synthesized at the cytoplasmic face of the inner membrane and then flipped across the membrane.
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