Publications by authors named "Vasconcelos U"

The pequi () is a typical fruit from the Brazilian Cerrado. From it, pequi pulp oil is extracted, a valuable product for cosmetic applications due to its high levels of unsaturated fatty acids and carotenoids. Carotenoids are antioxidant compounds that are easily oxidized.

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Article Synopsis
  • - Candida albicans is the main cause of oral candidiasis, and its growing resistance to drugs has sparked the search for better antifungal treatments, leading researchers to investigate the effects of (-)-fenchone.
  • - The study found that (-)-fenchone is effective against C. albicans, including strains resistant to miconazole, demonstrating strong antifungal properties with a Minimum Inhibitory Concentration (MIC) of 8 μg/mL.
  • - Negative effects on the fungus do not stem from cell wall or membrane damage, and although (-)-fenchone has some ability to prevent biofilm formation, it doesn't disrupt existing biofilms; it also showed low toxicity, suggesting it could be a viable treatment
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Candida albicans is the main fungal species involved in oral candidiasis, and its increasing resistance to pharmacological treatment encourages the search for improved antifungal agents. Lavandula dentata L. essential oil (LD-EO) has been recognized for its antimicrobial activity, but little is known about its role against oral C.

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This is the first study that describes the antifungal and anti-biofilm potential of O-alkylamidoximes against strains of Cryptococcus neoformans and Cryptococcus gattii. In vitro tests have shown that O-alkylamidoximes are capable of inhibiting fungal growth and biofilm formation of the C. neoformans and C.

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Patulin (PAT) is a natural product isolated from several species of fungi. Here, we evaluated the effect of PAT (62.5-4,000 ng/ml) in lipopolysaccharide (LPS)-activated murine peritoneal macrophages.

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Purpose: Certain ocular resident or pathogenic microbes may remain viable in the presence of multi-purpose disinfectant solutions (MPDSs), subsequently developing biofilms inside contact lens storage cases (CLSCs) which pose a risk of infection to wearers. This study evaluated the formation of ocular microbiota biofilms exposed to three top selling MPDS.

Methods: Crystal violet assay was carried out for the verification of biofilm formation.

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Pyocyanin was the first natural phenazine described. The molecule is synthesized by about 95% of the strains of From discovery up to now, pyocyanin has been characterised by a very rich and avant-garde history, which includes its use in antimicrobial therapy, even before the discovery of penicillin opened the era of antibiotic therapy, as well as its use in electric current generation. Exhibiting an exuberant blue colour and being easy to obtain, this pigment is the subject of the present review, aiming to narrate its history as well as to unveil its mechanisms and suggest new horizons for applications in different areas of engineering, biology and biotechnology.

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Carvacrol has been recognized as an efficient growth inhibitor of food pathogens. However, carvacrol oil is poorly water-soluble and can be oxidized, decomposed or evaporated when exposed to the air, light, or heat. To overcome these limitations, a carvacrol nanoemulsion was developed and its antimicrobial activity against food pathogens evaluated in this study.

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Pyocyanin is a typical virulence factor, a common Gram-negative rod responsible for a wide range of severe nosocomial infections. There is evidence indicating that pyocyanin has multiple biological activities, but little is known about anti-inflammatory properties. This study investigated pyocyanin effect on nitric oxide and cytokine production in lipopolysaccharide (LPS)-activated murine peritoneal macrophages.

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[reaction: see text] The synthesis of liquid crystal series 9a-d was achieved using the Buchwald protocol and Sonogashira reaction.

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