Do you have enough space? Habitat selection of insectivorous cave-dwelling bats in fragmented landscapes of Eastern Amazon.

Individual movements of bats are triggered by their life requirements, limited by their recognition of the environment and risks of moving, and mediated by habitat selection. Mining adds fragmentation and heterogeneity to landscapes, with poorly understood consequences to the life activities of the bats. Cave dwelling bats spend most of their life cycles within caves, and as they constantly forage in external landscapes, their contribution in the input of organic matter to the caves is of paramount importance to the subterranean biodiversity.

Differential effects of photophase on the reproductive behaviour of two species of medico-legal relevance, Peckia (Peckia) chrysostoma (Wiedemann, 1830) and Peckia (Sarcodexia) lambens (Wiedemann, 1830) (Diptera: Sarcophagidae).

The nocturnal behaviour and reproduction patterns of Sarcophagidae species during the scotophase are largely unexplored for species in the Neotropical region. The aim of this study was to assess the light regimes under which females of Peckia (Peckia) chrysostoma (Wiedemann, 1830) and Peckia (Sarcodexia) lambens (Wiedemann, 1830) would larviposit and understand how these variables influence intrauterine development in these flies. The experiments were conducted in an experimental room (lux = 100) in two independent experiments: I.

Transcriptomic analysis and epigenetic regulators in human oocytes at different stages of oocyte meiotic maturation.

Human oocytes are highly specialized cells with the capacity to store and regulate mRNAs during oocyte maturation, in preparation for post-fertilization steps. Here we performed single-oocyte transcriptomic analysis of human oocytes in three meitoic maturation stages - Germinal Vesicle (GV; n = 6), Metaphase I (MI; n = 6) and Metaphase II (MII; n = 7). Single-oocyte transcriptomic analysis revealed that the total number of expressed genes progressively decreased from GV to MII stages, with 9660 genes being transcribed in GV, 8734 in MI and 5889 in MII.

New mitochondrial genomes of three whip spider species from the Amazon (Arachnida, Amblypygi) with phylogenetic relationships and comparative analysis.

The complete mitochondrial genomes of the whip spiders Charinus carajas, C. ferreus, and Heterophrynus longicornis were sequenced, annotated, and compared with other mitogenomes of whip spiders and arachnids. The three new mitogenomes have the 37 genes usually observed in Metazoa: 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), and two ribosomal RNAs (rRNAs), plus a non-coding control region (CR).

Death, flies and environments: Towards a qualitative assessment of insect (Diptera) colonization of human cadavers retrieved from sites of death in Brazil.

Empirical data on decomposition ecology have long established blowflies (Calliphoridae) and flesh flies (Sarcophagidae) (Diptera) as the most frequent colonizers of carrion, especially at early stages of decomposition. However, the scarcity of studies based on human cadavers has hindered inferences about colonization of homicide victims in real case scenarios. We describe here a survey of insects associated with cadavers retrieved from the site of death in Northeastern Brazil, with emphasis on the association between species diversity and the surrounding environment.

Effect of sleep duration on child development in Fortaleza, Northeastern Brazil.

Objective: The present study's objective is to assess whether sleep duration affects Early Childhood Development (ECD). A prospective cohort study was carried out with 278 mother-child dyads in the city of Fortaleza, northeastern Brazil, with data collection every 6 months.

Method: The data used in this study are from the third (18 months) and fourth (24 months) survey waves.

Leveraging genomes to support conservation and bioeconomy policies in a megadiverse country.

The biodiversity crisis is a global phenomenon, and measures to monitor, stop, and revert the impacts on species' extinction risk are urgently needed. Megadiverse countries, especially in the Global South, are responsible for managing and protecting Earth's biodiversity. Various initiatives have started to sequence reference-level genomes or perform large-scale species detection and monitoring through environmental DNA.

Effects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL-cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial.

Background: Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction.

Methods: DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial.

Views of a non-probability sample of corresponding authors with retracted publications in biomedical fields about the impact of different types of retractions on researchers' careers.

Echoing Arturo Casadevall and Ferric Fang in their Reforming Science: Methodological and Cultural Reforms, "great human enterprises must undergo periodic cycles of self-examination and renewal to maintain their vigor". Especially in the last decade, the research culture has undergone such cycles, partially driven by countercultural transformations that have been reshaping assumptions towards reward-deserving achievements. Addressing retractions is among the challenges in this culture.

X-chromosome inactivation pattern and telomere length in recurrent pregnancy loss.

Recurrent pregnancy loss is a reproductive disorder affecting about 1 to 5 % of pregnant women worldwide that requires our attention, especially considering that about 50 % of cases are idiopathic. The present study is focused on testing a possible association between extreme skewed X-chromosome inactivation patterns and/or shortened telomeres with idiopathic cases since both are considered non-consensual potential causes underlying recurrent pregnancy loss in the scientific community. For this purpose, two groups of women were analyzed and compared: a group of women with idiopathic recurrent pregnancy loss and a second group of age-matched women with proven fertility, and both X-chromosome inactivation patterns and telomere length were measured and compared from maternal DNA extracted from peripheral blood.

Complete mitochondrial genomes of three vulnerable cave bat species and their phylogenetic relationships within the order Chiroptera.

The IUCN Red List of Threatened Species contains 175 Brazilian bat species that are threatened by extinction in some degree. From this perspective, it is essential to expand the knowledge about the genetic diversity of vulnerable bats. Genomic sequencing can be useful to generate robust and informative genetic references, increasing resolution when analyzing relationships among populations, species, or higher taxonomic levels.

Dietary Adequacy of Individuals with Cardiovascular Disease According to Clinical Guidelines in the Brazilian Cardioprotective Nutritional (BALANCE).

Background: Achieving nutritional goals established by scientific societies is a constant challenge and not always achieved.

Objective: To investigate the dietary adequacy of individuals with cardiovascular disease (CVD), participants in the Cardioprotective Brazilian Food Program residing in the Northeast region of Brazil, according to the recommendations of the Brazilian Society of Cardiology (SBC).

Methods: Cross-sectional analysis with data from the study implementing the Brazilian Cardioprotective Diet (DICA BR), which evaluated individuals with CVD treated in specialized cardiovascular health centers in eight states in the Northeast region.

New taxonomic insights for Brazilian Reitter (Coleoptera: Staphylinidae: Pselaphinae), including three new species and their mitochondrial genomes.

Here we present a taxonomic treatment for the Brazilian species of (Reitter, 1882), including the description of three new species ( Asenjo & Valois , Asenjo & Valois and Asenjo & Valois ) from the Quadrilátero Ferrífero (Minas Gerais, Brazil). In addition, we designated lectotypes for the Brazilian species of species-group 2, (Raffray, 1898), (Reitter, 1888), (Reitter, 1888), (Raffray, 1898), and (Schaufuss, 1887), besides recognizing the holotype for (Reitter, 1882), (Raffray, 1898), and (Raffray, 1898). The mitochondrial genomes (mitogenomes) of the three new species are presented, for which we present the phylogenetic placement among Staphylinidae with previously published data.

The InBIO Barcoding Initiative Database: DNA barcodes of Portuguese moths.

Background: The InBIO Barcoding Initiative (IBI) Dataset - DS-IBILP08 contains records of 2350 specimens of moths (Lepidoptera species that do not belong to the superfamily Papilionoidea). All specimens have been morphologically identified to species or subspecies level and represent 1158 species in total. The species of this dataset correspond to about 42% of mainland Portuguese Lepidoptera species.

Syncytiotrophoblast Markers Are Downregulated in Placentas from Idiopathic Stillbirths.

The trophoblast cells are responsible for the transfer of nutrients between the mother and the foetus and play a major role in placental endocrine function by producing and releasing large amounts of hormones and growth factors. Syncytiotrophoblast cells (STB), formed by the fusion of mononuclear cytotrophoblasts (CTB), constitute the interface between the foetus and the mother and are essential for all of these functions. We performed transcriptome analysis of human placental samples from two control groups-live births (LB), and stillbirths (SB) with a clinically recognised cause-and from our study group, idiopathic stillbirths (iSB).

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.

Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool compounds for these kinases has significantly hampered our understanding of their cellular functions and therapeutic potential. Here, we describe the structure-based development of potent inhibitors of VRK1, a kinase highly expressed in various tumor types and crucial for cell proliferation and genome integrity.

Diversity and Flight Patterns of Caddisflies (Trichoptera) in an Atlantic Forest Fragment: Implications for Species Conservation in Threatened Ecosystems.

Anthropogenic activities have decimated the Atlantic Forest domain (AF) and increased the pressure on freshwater biota, such as Trichoptera, which is the most affected order by the current insect decline. Adult mobility is crucial for the colonisation of new environments unconnected by water sources. In this article, we describe the assemblage of caddisflies in a preserved AF fragment related to their functional feeding group and provide empirical data on the patterns of horizontal and vertical flight.

Bionomics, reproductive traits and assessment of forensic relevance of Peckia (Peckia) chrysostoma (Wiedemann, 1830) (Diptera: Sarcophagidae).

Peckia (Peckia) chrysostoma (Wiedemann, 1830) (Diptera: Sarcophagidae) is a colonizer of cadavers in the Neotropical Region. Nevertheless, data on development for the P. (P.

Physical Activity at Different Life Stages and Its Consequence on the Initial Immunization and Inflammatory Response Against COVID-19.

Background: To evaluate the influence of previous physical activity (PA) during childhood, adolescence, and current PA practice on the production of antibodies and inflammatory response between the first and second doses of the COVID-19 vaccine.

Methods: Fifty-nine men and 56 women were evaluated before the first vaccine, and 12 weeks later, blood samples were taken to quantify production of anti-severe acute respiratory syndrome coronavirus-2 immunoglobulin G antibodies and cytokines. Previous PA during childhood and adolescence was self-referred, and current PA was assessed using the International Physical Activity Questionnaire.

Adequacy of Fatty Acids Consumption Among Individuals in Secondary Cardiovascular Prevention.

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases.

Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence.

Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial".

Organellar-genome analyses from the lycophyte genus L. show one of the highest frequencies of RNA editing in land plants.

RNA editing is a post-transcriptional process that challenges the central dogma of molecular biology by modifying RNA sequences, introducing nucleotide changes at specific sites, and generating functional diversity beyond the genomic code, especially when it concerns organellar transcripts. In plants, this phenomenon is widespread, but its extent varies significantly among species and organellar genomes. Among land plants, the heterosporous lycophytes (i.

Night Shift Work and Sleep Disturbances in Women: A Scoping Review.

This scoping review aimed to synthesize evidence on sleep disturbances in female shift workers. The update Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used. Twelve studies were included, four of which used actigraphy to assess sleep duration, efficiency, and latency.