Publications by authors named "Vasco Lucas"
Article Synopsis
- Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition caused by a mutation in the LMNA gene, leading to rapid aging in children, often resulting in death by their early teens due to cardiovascular issues.
- Research indicates that the hormone ghrelin can enhance autophagy, lower progerin levels, and reduce symptoms of premature aging in HGPS fibroblasts.
- In HGPS mouse models, administering ghrelin not only improves health by reversing signs of aging and preventing weight loss but also extends their lifespan, suggesting a promising therapeutic approach for HGPS and similar age-related diseases.
An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. Key traits of senescent cells include cell cycle arrest, apoptosis resistance, and secretome shift to senescence-associated secretory phenotype resulting in increased secretion of various intermediate bioactive factors important for senescence pathophysiology.
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