Propofol exposure in pregnant rats induces neurotoxicity and persistent learning deficit in the offspring.

Propofol is a general anesthetic widely used in surgical procedures, including those in pregnant women. Preclinical studies suggest that propofol may cause neuronal injury to the offspring of primates if it is administered during pregnancy. However, it is unknown whether those neuronal changes would lead to long-term behavioral deficits in the offspring.

Effects of prenatal propofol exposure on postnatal development in rats.

Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2 h (2HP) on gestational day 18.

The effect of perioperative ketorolac on pain control in pregnancy termination.

Background: The study was conducted to evaluate the effect of perioperative ketorolac on pain associated with first-trimester aspiration abortion.

Study Design: A double-blind, randomized, placebo-controlled trial was performed involving pregnant women up to 14 weeks' gestation who desired pregnancy termination. Subjects were randomized to receive ketorolac 30 mg intravenously (n=31) or placebo (n=45) at the time of induction of anesthesia.