Phytochemical composition, in vitro cytotoxicity and in silico ADME/Tox analysis of the active compounds of Kunth. extracts with promising anticancer potential.

Unlabelled: This study investigated the anticancer phytocompounds in leaf extracts of Kunth. Quantitative analysis of the phytochemical composition showed high levels of primary metabolites: carbohydrates (45.11 ± 2.

Food contaminants: Impact of food processing, challenges and mitigation strategies for food security.

Food preparation involves the blending of various food ingredients to make more convenient processed food products. It is a long chain process, where each stage posing a risk of accumulating hazardous contaminants in these food systems. Protecting the public health from contaminated foods has become a demanding task in ensuring food safety.

Unraveling the impact of nanopollution on plant metabolism and ecosystem dynamics.

Nanopollution (NPOs), a burgeoning consequence of the widespread use of nanoparticles (NPs) across diverse industrial and consumer domains, has emerged as a critical environmental issue. While extensive research has scrutinized the repercussions of NPs pollution on ecosystems and human health, scant attention has been directed towards unraveling its implications for plant life. This comprehensive review aims to bridge this gap by delving into the nuanced interplay between NPOs and plant metabolism, encompassing both primary and secondary processes.

Semantic segmentation of urban environments: Leveraging U-Net deep learning model for cityscape image analysis.

Semantic segmentation of cityscapes via deep learning is an essential and game-changing research topic that offers a more nuanced comprehension of urban landscapes. Deep learning techniques tackle urban complexity and diversity, which unlocks a broad range of applications. These include urban planning, transportation management, autonomous driving, and smart city efforts.

Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer.

Dynamic interactions within the tumor micro-environment drive patient response to immune checkpoint inhibitors. Existing preclinical models lack true representation of this complexity. Using a Head and Neck cancer patient derived TruTumor histoculture platform, the response spectrum of 70 patients to anti-PD1 treatment is investigated in this study.

Conservation linkages of endangered medicinal plant and exploration of phytochemicals, pharmaceutical screening and in silico validation against diabetics using in vivo wild and in vitro regenerated plant Wight.

Unlabelled: Wight. is an important endangered medicinal plant belonging to the family Asclepiadaceae. In this study, an efficient protocol has been developed for using nodal explants for callus induction and direct organogenesis.

Brain image fusion-based tumour detection using grey level co-occurrence matrix Tamura feature extraction with backpropagation network classification.

Most challenging task in medical image analysis is the detection of brain tumours, which can be accomplished by methodologies such as MRI, CT and PET. MRI and CT images are chosen and fused after preprocessing and SWT-based decomposition stage to increase efficiency. The fused image is obtained through ISWT.

Organosulfur Compound Identified from Striga angustifolia (D. Don) C.J. Saldanha Inhibits Lung Cancer Growth and Induces Apoptosis via p53/mTOR Signaling Pathway.

The Striga angustifolia (D. Don) C.J.

Successful Third Kidney Transplantation in a Nigerian Kidney Transplant Center: A Case Report.

Patients with end-stage renal disease have limited options in the course of their management. Kidney transplantation (KT) remains the gold standard for the management of renal replacement therapy. There is increasing evidence supporting the viability of third and fourth KTs.

Exploration of phytochemicals and probing potential effects of active extract on PACAP 38 and its nociceptor in the human trigeminovascular system.

Unlabelled: Several tribal medicinal systems assert anti-migraine and common headache-remedying properties in all parts of (L.f.) Druce.

Anti-adipogenic β-sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression.

Triterpenes and phytosterols enriched herbal formulations are known for glucose regulation and lipid metabolism. In this study, triterpenes and phytosterols from Moringa oleifera stem bark have been tested for their role in adipocyte differentiation. Chromatographic analysis revealed a wide range of phenolics, highlighting the presence of flavonoids (kaempferol, quercetin, and rutin), terpenoids (lupeol), and phytosterol (stigmasterol, β-sitosterol).

,-Ru(II)--cymene-poly(-vinylpyrrolidone) surface functionalized gold nanoparticles: from organoruthenium complex to nanomaterial for antiproliferative activity.

Organometallic Ru-arene complexes are promising as anticancer agents, but the lack of tumor uptake and poor solubility in the physiological medium impede their development. In order to deal with these challenges, we developed gold nanoparticles coated with Ru(arene)-functionalized PNVP-Py, where PNVP-Py is pyridine end-functionalized poly(N-vinylpyrrolidone). It is demonstrated that these particles exhibit higher anti-proliferative activity than the individual organometallic ruthenium(ii) complex of the type [Ru(η6-p-cymene)(NN)Cl]PF6, where NN is bis(4-methoxyphenylimino)acenaphthene, against colorectal adenocarcinoma cell lines.

The burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population: Results from a statewide sentinel-based population survey in Karnataka, India.

Objective: To estimate the burden of active infection and anti-SARS-CoV-2 IgG antibodies in Karnataka, India, and to assess variation across geographical regions and risk groups.

Methods: A cross-sectional survey of 16,416 people covering three risk groups was conducted between 3-16 September 2020 using the state of Karnataka's infrastructure of 290 healthcare facilities across all 30 districts. Participants were further classified into risk subgroups and sampled using stratified sampling.

Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults.

Background & Aims: Human beings are often driven to exhibit dietary preference according to their hedonic characteristics. Though previous studies proposed that the fat taste preference of an obese individual was associated with BMI, the perception of fat taste differs for every individual. The genetic variation among populations in taste receptor genes such as CD36 may be a contributing factor for this difference.

Integrated Urban Mobility Policies in Metropolitan Areas: A System Dynamics Approach for the Rhine-Ruhr metropolitan region in Germany.

In today's world, urban systems play an important role in sustainable economic development. In particular, urbanisation trends and the increasing demands of urban mobility place additional pressure on existing transportation infrastructure, and this creates new challenges for urban planners in terms of developing integrated and sustainable urban mobility policies. Here, we take a novel and holistic approach to analysing transformative pathways towards sustainable urban mobility, considering the complex dynamics in metropolitan regions.

Morphological traits of drought tolerant horse gram germplasm: classification through machine learning.

Background: Horse gram (Macrotyloma uniflorum (Lam.) Verdc.) is an underutilized pulse crop with good drought resistance traits.

A simple and efficient Agrobacterium-mediated in planta transformation protocol for horse gram (Macrotyloma uniflorum Lam. Verdc.).

Background: Recalcitrant nature is a major constraint for the in vitro regeneration and genetic transformation of leguminous species members. Therefore, an improved genetic transformation in horse gram has been developed via in planta method, in which Agrobacterium strain harboring binary vector pCAMBIA2301 was used for the transformation. Several factors affecting in planta transformations were put forth viz.

Insights on modulators in perception of taste modalities: a review.

A major challenge in taste research is to overcome the flavour imperfections in food products and to build nutritious strategies to combat against obesity as well as other related metabolic syndromes. The field of molecular taste research and chemical senses has contributed to an enormous development in understanding the taste receptors and mechanisms of taste perception. Accordingly, the development of taste-modifying compounds or taste modulators that alter the perception of basic taste modalities has gained significant prominence in the recent past.

A Self Assistive Device for Deaf & Blind People Using IOT : Kathu-Kann Thaan Thunai Eyanthiram.

This paper presents Google speech API based aid for deaf and blind people. The live streaming speech on the microphone is sent to Google API server which converts the speech signal into text and displaying onto a LCD screen and amplifies the speech via speaker. The aid will use Request procedure protocol to send the encoded Mp3 audio to Google API server where the speech signal is converted into suitable text and sent back to the Raspberry pi using repeated request protocol.

ECG Signal Classification Using Various Machine Learning Techniques.

Electrocardiogram (ECG) signal is a process that records the heart rate by using electrodes and detects small electrical changes for each heat rate. It is used to investigate some types of abnormal heart function including arrhythmias and conduction disturbance. In this paper the proposed method is used to classify the ECG signal by using classification technique.

Effect of biosynthesized gold nanoparticles by Sargassum swartzii in alloxan induced diabetic rats.

Biosynthesis of gold nanoparticles (AuNPs) using Sargassum swartzii and its anti-diabetic effect were studied using male wistar Albino rats. Formation of AuNPs were confirmed by UV-vis spectroscopy, Fourier transformed infrared (FTIR) spectroscopy, High-Resolution transmission electron microscopy (HR-TEM) and X-ray diffraction (XRD). Fasting blood glucose levels, serum insulin, hemoglobin and glycosylated hemoglobin levels in diabetic treated rats with AuNPs were significantly decreased compared to the control group.

Dietary supplementation of Zeolite on growth performance, immunological role, and disease resistance in Channa striatus against Aphanomyces invadans.

Epizootic Ulcerative Syndrome (EUS) caused by Aphanomyces invadans which is a primary fungal parasitic pathogen, inflicts serious economic loss in tropical freshwater fish including snakehead murrel, Channa striatus. In the present study with an aim to circumvent the adverse effects of the traditional measures in graded levels (2%, 4%, and 6%) of Zeolite enriched diet on growth performance, hematology, immunological response, and disease resistance in C. striatus against A.

A 180-V Integrated Linear Amplifier for Ultrasonic Imaging Applications in a High-Voltage CMOS SOI Technology.

This brief presents a monolithically integrated fully differential linear HV amplifier as the driver of an ultrasonic transducer. The linear amplifier is capable of transmitting HV arbitrary signals with a very low harmonic distortion, which is suitable for tissue harmonic imaging and other ultrasonic modes for enhanced imaging quality. The amplifier is designed and implemented using the 0.

Value of pentraxin-3 and galectin-3 in acute coronary syndrome: a short-term prospective cohort study.

Background: Acute coronary syndrome (ACS) continues to be a leading cause of morbidity and mortality worldwide. Galectin-3 and pentraxin-3 are two prognostic biomarkers that have been studied in heart failure (HF). However, there are limited data on these biomarkers in the ACS population.

Palatogingival groove mimicking as a mutilated root fracture in a maxillary lateral incisor: a case report.

This article presents a case of a palatogingival groove (PPG) in tooth No. 12 that was misdiagnosed as a mutilated root fracture. A PPG is a developmental anomaly that predisposes a tooth to a severe periodontal defect.