Physicochemical analysis of chitosan oligosaccharide revealed its usefulness in effective delivery of drugs.

Chitosan oligosaccharides are biopolymers with a wide range of potential applications in various fields. This biopolymer is diverse and promising, and current research is investigating its capabilities for improved drug delivery. As chitosan oligosaccharide has the potential to be used as a drug delivery option, the purpose of this study was to examine its physicochemical characteristics and its potential for drug delivery.

PARP in the neuropathogenesis of cytomegalovirus infection - Possible role and therapeutic perspective.

Cytomegalovirus infects the majority of the population globally. Congenital CMV infection acquired through primary maternal infection in pregnancy is the most common intrauterine infection with a high mortality rate due to severe long-term neurodevelopmental sequelae. The demyelination and neuroinflammation during CMV infection have been attributed to altered immune response and ROS-mediated apoptosis.

Production and characterization of a novel thermostable laccase from Bacillus licheniformis VNQ and its application in synthesis of bioactive 1,4-naphthoquinones.

Bacterial laccases have proven to be a potential biocatalyst for various industrial applications due to their remarkable catalytic and stability properties. In this study, a novel thermostable laccase was produced from the bacterium Bacillus licheniformis VNQ by submerged fermentation. The specific activity of crude and purified laccase was found to be 13.

Iron Oxide Nanoparticles Affects Behaviour and Monoamine Levels in Mice.

Iron oxide (FeO) nanoparticles (NPs) attract the attention of clinicians for its unique magnetic and paramagnetic properties, which are exclusively used in neurodiagnostics and therapeutics among the other biomedical applications. Despite numerous research findings has already proved neurotoxicity of FeO-NPs, factors affecting neurobehaviour has not been elucidated. In this study, mice were exposed to FeO-NPs (25 and 50 mg/kg body weight) by oral intubation daily for 30 days.

Production of highly thermo-tolerant laccase from novel thermophilic bacterium Bacillus sp. PC-3 and its application in functionalization of chitosan film.

In this study, a novel thermophilic bacterial strain was isolated from Tattapani hot spring located in the Chhattisgarh state of India. The laccase was produced via submerged fermentation and purified by ammonium sulfate precipitation and anion exchange chromatography up to 13.7 fold.

Iron Oxide Nanoparticles Induces Cell Cycle-Dependent Neuronal Apoptosis in Mice.

Iron oxide (FeO) nanoparticles (NPs) with its unique magnetic and paramagnetic properties are popular in biomedical applications. Some of their neurotoxic mechanisms due to repeated administration are proven. However, we speculate that the neuronal damage might be due to apoptosis resulting from unusual cell cycle entry.

Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice.

The cardiotoxicity of iron oxide nanoparticles (FeO-NPs) in mice was investigated. The mice were intraperitoneally administered with FeO-NPs at the dose of 25 and 50 mg/kg bw for 30 days at seven days interval. In vivo MRI analysis reveals the FeO-NPs accumulation in the cardiac system.

Dataset on antitumor properties of silver nanoparticles from (L.) seed on Dalton Lymphoma Ascites (DLA) tumor: Facile and biocompatible approach.

The dataset depicted in this article related to our earlier article entitled "Phytofabrication and encapsulated of silver nanoparticles from " (Saradha Devi et al., 2017) [1], which reports the characteristic features (UV Visible spectra, FTIR, SEM, TEM, DLS, Zeta potential and XRD analysis) of the biosynthesised silver nanoparticles (AgNPs). In this context, the present dataset was provided to identify the antioxidant, antitumor and apoptotic (in DLA cells) properties with the synthesized AgNPs.

Neurobehavioural Toxicity of Iron Oxide Nanoparticles in Mice.

Iron oxide nanoparticles (FeO-NPs) are widely used in various biomedical applications, extremely in neurotheranostics. Simultaneously, FeO-NP usage is of alarming concern, as its exposure to living systems causes deleterious effects due to its redox potential. However, study on the neurobehavioural impacts of FeO-NPs is very limited.