Publications by authors named "Varun A Sane"
Article Synopsis
- The research focuses on the fruit fly Drosophila melanogaster as a crucial model in neuroscience, aided by extensive resources like the FlyWire whole-brain connectome and a hierarchical annotation of neuron classes and types.
- The study reveals 8,453 annotated cell types, with 4,581 being newly identified, highlighting the complexity of the fly brain and emphasizing the difficulty in reidentifying some hemibrain cell types in FlyWire.
- A new definition of cell type is proposed based on cell similarities across different brains, and the study illustrates findings related to neuron connectivity, structural stability, and a consensus atlas for the fly brain's neuroanatomy, supporting future comparative studies.
Article Synopsis
- The fruit fly is a key model organism in neuroscience due to its complex behaviors and accessible nervous system, bolstered by collaborative genetic resources.*
- The FlyWire project has produced the first complete brain connectome of an adult fruit fly, providing a detailed catalog of approximately 130,000 neurons, including 4,552 cell types.*
- Analysis indicated that while some neuronal connections were stable, others showed variability across individuals, revealing complexities in brain function and suggesting some cell types from previous studies may not be reliably identified in this new dataset.*
Animals navigate within their surrounding environment to find food, shelter, and mates; this behavior forms one of the most basic means of survival. The vertebrate hippocampus acts as an integration hub for varied dynamic processes such as attention, memory, perception, and decision-making. This ultimately allows an animal to move efficiently in its surroundings in search of food or to escape from predators.
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