Zooming towards Rapid Qualitative Research for Implementation Science.

Qualitative research serves a critical role in improving our understanding and delivery of healthcare. However, there are multiple barriers to the efficient practice of qualitative research, including conducting interviews. Advances in language processing technology, coupled with technocultural shifts spurred by the COVID pandemic, present opportunities to overcome many of these barriers.

Exploring implementation outcomes in the clinical trial context: a qualitative study of physician trial stakeholders.

Introduction: Cancer clinical trials can be considered evidence-based interventions with substantial benefits, but suffer from poor implementation leading to low enrollment and frequent failure. Applying implementation science approaches such as outcomes frameworks to the trial context could aid in contextualizing and evaluating trial improvement strategies. However, the acceptability and appropriateness of these adapted outcomes to trial stakeholders are unclear.

Better Understanding the Timing Of Androgen Deprivation Trial Outcomes: Impacts of Prior Androgen Deprivation Therapy.

Background: The Timing Of Androgen Deprivation (TOAD) trial found an overall survival benefit for immediate vs delayed androgen deprivation therapy (ADT) for prostate-specific antigen (PSA)-relapsed or noncurable prostate cancer. However, broad eligibility criteria allowed entry of a heterogeneous participant group, including those with prior ADT exposure, raising concerns about subsequent androgen sensitivity. For these reasons, we completed previously specified subgroup analyses to assess if prior ADT was associated with ADT timing efficacy after PSA relapse.