Publications by authors named "Varsha Thoppey-Manoharan"
Our study demonstrates the use of "IF-THEN" SynNotch-gated CAR-T cells targeting CD33 and CD123 in AML reduces off-tumor toxicity. This strategy enhances T-cell phenotype, improves expansion, preserves HSPCs, and mitigates cytokine release syndrome-addressing critical limitations of existing AML CAR-T therapies.
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- Understanding the diffuse invasion of glioblastoma cells is crucial for addressing tumor aggressiveness and resistance to treatment, which negatively impacts patient prognosis.
- The study utilizes a novel computational method to analyze GBM xenografts, distinguishing human tumor cells from the mouse tumor microenvironment (TME), resulting in a detailed overview of 15 tumor cell programs linked to invasion pathways.
- The findings suggest targeted interventions on tumor and TME components could lead to improved therapies by revealing compensatory mechanisms that might aid in developing more effective combination treatments.
Advances in molecular profiling have facilitated generation of large multi-modal datasets that can potentially reveal critical axes of biological variation underlying complex diseases. Distilling biological meaning, however, requires computational strategies that can perform mosaic integration across diverse cohorts and datatypes. Here, we present mosaicMPI, a framework for discovery of low to high-resolution molecular programs representing both cell types and states, and integration within and across datasets into a network representing biological themes.
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