Salivary lactate dehydrogenase as a prognostic marker in oral squamous cell carcinoma patients following surgical therapy.

The objective of the present study was to assay the salivary levels of lactate dehydrogenase in patients with OSCC in comparison to healthy controls and to assess the changes in salivary levels of lactate dehydrogenase as prognostic markers of surgical therapy in oral squamous cell carcinoma patients. A case control study was undertaken comprising of 20 patients who were clinically diagnosed and histopathologically proven with oral squamous cell carcinoma and compared with 20 age and gender matched controls. Unstimulated whole saliva (2 ml) was collected by the spit method from every subject.

Histopathological differentiation of oral squamous cell carcinoma and salivary lactate dehydrogenase: A biochemical study.

Context: Early diagnosis of oral cancer is a priority health objective, in which oral health professionals may play a pivotal role. Detection should lead to less damage from cancer therapy and to a better prognosis.

Aims: The aim was to estimate and compare the salivary lactate dehydrogenase (LDH) levels in various histological differentiation of oral squamous cell carcinoma (OSCC) patients and normal subjects.