Publications by authors named "Varsha Jahoriya"
Article Synopsis
- Chemotherapy remains the primary treatment for many cancers, but its effectiveness is limited by drug resistance often linked to lysosomal functions in cells.
- Lysosomes play a dual role by sequestering chemotherapeutic drugs, thus lowering their availability and enhancing resistance; they also contribute to cancer progression through enzymatic activity and triggering cell death.
- The review discusses mechanisms of lysosomal drug sequestration and explores strategies to target lysosomes, aiming to reverse drug resistance and improve cancer treatment outcomes.
A significant advancement in the field of epigenetic drug discovery has been evidenced in recent years. Epigenetic alterations are hereditary, nevertheless reversible variations to DNA or histone adaptations that regulate gene function individualistically of the fundamental sequence. The design and synthesis of various drugs targeting epigenetic regulators open a new door for epigenetic-targeted therapies to parade worthwhile therapeutic potential for haematological and solid malignancies.
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