Publications by authors named "Varnum C"
Background: The Knee Outcome Survey - Activities of Daily Living Scale (KOS-ADLS) is a patient-reported outcome measure (PROM) developed to assess symptoms and functional limitations in patients with various knee disorders. The aim of this study was to translate and culturally adapt the KOS-ADLS to Danish and to evaluate the psychometric properties of the Danish version (KOS-ADLS-DK) in patients with anterior cruciate ligament (ACL) injury.
Methods: The KOS-ADLS was translated and culturally adapted to Danish in accordance with recommended guidelines.
Background: Following the implementation of the fast-track protocol in total hip arthroplasty (THA), total knee arthroplasty (TKA), and unicompartmental knee arthroplasty (UKA), the median length of stay (LOS) has been significantly reduced without an increase in readmissions. However, it is unclear if the reduction in LOS is at the expense of an increase in nonhome discharge. The aim of this study was to investigate the discharge destination among THA, TKA, and UKA patients.
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- The study aimed to improve the prediction of outcomes after total hip arthroplasty (THA) by examining the role of inflammatory biomarkers in blood and cerebrospinal fluid (CSF) related to osteoarthritis and pain.
- Researchers analyzed data from 50 patients, assessing changes in pain and disability 12 months post-surgery, while considering factors like age, sex, and BMI.
- Results showed that preoperative systemic inflammation in blood was linked to better postoperative outcomes, while neuroinflammation was tied to preexisting pain, suggesting that inflammatory biomarkers could help select patients for THA more effectively in the future.
Article Synopsis
- - The study aimed to assess day-case surgery success rates for primary total hip arthroplasty (THA), total knee arthroplasty (TKA), and medial unicompartmental knee arthroplasty (mUKA), investigating the reasons for patients not being discharged on the same day despite eligibility.
- - Conducted over a year with 6,142 patients, the study found that 34% of THA and TKA patients and 52% of mUKA patients were eligible for day-case surgery, with mUKA showing the highest success rates (72%) when surgeries were completed before 1:00 pm.
- - Key reasons for day-case failures included issues with patient mobilization,
Background: Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical treatment such as resistance training.
Methods: We conducted a multicenter, randomized, controlled trial to compare total hip replacement with resistance training in patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery. The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function).
Article Synopsis
- Preoperative psychopharmacological treatment (PPT) was analyzed to see if it negatively impacts patient-reported outcomes following hip and knee surgeries, focusing on a multicenter fast-track study in Denmark.
- The study included over 7,200 patients and tracked their health improvements for up to 24 months through various scoring systems.
- Results indicated that while PPT did not correlate with worse outcomes at the 12-month mark, patients receiving PPT had consistently lower scores both at baseline and after surgery compared to those who did not.
Background And Purpose: Metabolic syndrome (MetS) affects more than 60% of the patients having a hip or knee arthroplasty due to osteoarthritis. As it is debated whether metabolic syndrome increases the risk of complications, we aimed to investigate the length of stay (LOS) and risk of readmission at 30 and 90 days after surgery, including causes of readmission.
Methods: We conducted a prospective cohort study of 2,901 patients undergoing hip and knee arthroplasty from May 2017 to November 2019.
Background: Evidence on how to improve daily physical activity (PA) levels following total knee arthroplasty (TKA) or medial uni-compartmental knee arthroplasty (mUKA) by motivational feedback is lacking. Moreover, it is unknown whether a focus on increased PA after discharge from the hospital improves rehabilitation, physical function, and quality of life. The aim of this randomized controlled trial (RCT) nested in a prospective cohort is (a) to investigate whether PA, physical function, and quality of life following knee replacement can be increased using an activity monitoring device including motivational feedback via a patient app in comparison with activity monitoring without feedback (care-as-usual), and (b) to investigate the potential predictive value of PA level prior to knee replacement for the length of stay, return to work, and quality of life.
View Article and Find Full Text PDFAims: The influence of metabolic syndrome (MetS) on the outcome after hip and knee arthroplasty is debated. We aimed to investigate the change in patient-reported outcome measure (PROM) scores after hip and knee arthroplasty, comparing patients with and without MetS.
Methods: From 1 May 2017 to 30 November 2019, a prospective cohort of 2,586 patients undergoing elective unilateral hip and knee arthroplasty was established in Denmark.
Article Synopsis
- Total knee arthroplasty (TKA) can lead to inflammation and significant pain, and this study explores how pain catastrophizing impacts acute postoperative pain and inflammatory markers (CRP) associated with TKA.
- The research involved 119 patients and included analyses of pain and CRP levels at 24 and 48 hours post-surgery to assess correlations.
- Findings indicate no significant relationship between preoperative or postoperative CRP levels and pain experienced or pain catastrophizing, suggesting that CRP may not be a reliable marker for assessing acute pain after TKA in patients treated with preoperative glucocorticoids.
Background And Purpose: Prosthetic joint infection (PJI) following total hip arthroplasty (THA) has a severe impact on patients. We investigated the risk of second revision and mortality following first-time revision due to PJI.
Methods: We identified 1,669 first-time revisions including 416 treated with debridement, antibiotics, and implant retention (DAIR) from the Danish Hip Arthroplasty Register (DHR).
Background: As healthcare systems evolve, individuals are expected to be more involved in managing their health and rehabilitation. A wireless medical accelerometer (SENS motion®) has been developed to collect objective data on physical activity. The number of patients requiring knee replacement is rising, but the motivational effect of medical accelerometers in the rehabilitation after knee replacement remains unexplored.
View Article and Find Full Text PDFBackground: Restoring maximal muscle strength of the knee extensors (KE) and knee flexors (KF) following anterior cruciate ligament (ACL) injury and ACL reconstruction is of great importance to reduce the re-injury rate after ACL reconstruction and to reduce the risk of knee osteoarthritis. Therefore, it is essential that clinicians and healthcare providers use valid and reliable measures to assess knee muscle strength to ensure a safe return to sport.
Purpose: To evaluate the reliability (test-retest reliability, inter-tester reliability and test-retest agreement) and validity (concurrent validity, convergent validity and ForceFrame (FF) vs.
The most frequent indication for total hip arthroplasty (THA) is hip osteoarthritis. THA is inserted to improve function, reduce pain, and improve quality of life. Results are generally good, and 90-95% of the patients are satisfied.
View Article and Find Full Text PDFBackground: The aim of our study was to compare implant survival rates of different total hip arthroplasty (THA) bearings in the Nordic Arthroplasty Register Association.
Methods: All conventional primary THAs performed between 2005 and 2017 in patients aged more than 55 years who had primary osteoarthritis were studied. Metal-on-highly cross-linked polyethylene (MoXLP), ceramic-on-highly cross-linked polyethylene (CoXLP), ceramic-on-ceramic (CoC), and metal-on-metal (MoM) bearings were included.
Which patients need anterior cruciate ligament reconstruction after initial treatment with rehabilitation? A scoping review.
Knee Surg Sports Traumatol Arthrosc
July 2024
Purpose: Some patients with anterior cruciate ligament (ACL) injury initially treated with rehabilitation need ACL reconstruction (ACLR); yet, it is unclear what characterizes these patients. This review aimed to describe predictors for ACLR in patients initially treated with rehabilitation.
Methods: A systematic literature search was performed in the Cochrane, Embase, Medline, SportsDiscus and Web of Science databases from inception to 21 February 2023.
Background: The effect of metabolic syndrome (MetS) on the risk of revision after hip and knee arthroplasty is debated. The aim of our study was to investigate the risk of short-term (minimum 2.7 years) revision due to periprosthetic joint infection (PJI) after hip and knee arthroplasty.
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- This study evaluated factors that predict pain levels for patients after total knee arthroplasty, focusing on the days 2-7 post-surgery.
- It analyzed data from 227 patients to determine how preoperative and early postoperative factors, like pain levels and demographics, influence pain outcomes.
- Findings indicated that pain measured 24 hours after surgery is a strong predictor of pain during days 2-7, while preoperative pain only had a weak correlation.
Purpose: Comorbidity level is a predictor of infection in the first 30 days after hip fracture surgery. However, the roles of individual comorbid diseases as predictors of infection remain unclear. We investigated individual major comorbid diseases as predictors of infection after hip fracture surgery.
View Article and Find Full Text PDFPsychopharmacological treatment in patients planned for hip or knee replacement.
Basic Clin Pharmacol Toxicol
July 2024
Article Synopsis
- Psychopharmacological medications might increase the length of hospital stays and readmissions after hip and knee surgeries, suggesting that pausing these medications temporarily could be beneficial.
- A study involving 482 patients undergoing joint replacements in Denmark found that most were on antidepressants, mainly SSRIs and SNRIs, with a majority receiving long-term treatment initiated by general practitioners.
- The findings indicate that temporarily stopping these antidepressants might be practical for hip and knee replacement patients, warranting further research through a randomized controlled trial.
Article Synopsis
- * A prospective study involved 2,756 patients, where 37% were eligible for same-day discharge based on specific criteria, and 21% were actually discharged that day, marking a significant increase compared to pre-pandemic discharge rates.
- * The findings suggest that outpatient procedures are feasible in public healthcare settings, with expectations that success rates will improve as hospitals gain more experience with the protocol.
Article Synopsis
- The study focuses on understanding the impact of perioperative diabetes management on patient outcomes after hip and knee surgeries, considering the complexity of diabetes treatment guidelines and the limited existing data.
- A multicenter observational study will be conducted across 8 Danish arthroplasty centers, involving 1400 diabetic patients undergoing fast-track surgeries from September 2022 to December 2025, with follow-up lasting 90 days post-surgery.
- The primary goals are to evaluate hospital length of stay and readmission rates, while secondary outcomes include the relationship between diabetes treatment and other factors related to patient recovery and complications.
: Danish surveillance data indicated a higher risk of revision due to prosthetic joint infection (PJI) following total hip arthroplasty (THA) performed during the summer season. We investigated the association between summer and revision risk following primary THA. : This study identified 58 449 patients from the Danish Hip Arthroplasty Register (DHR) with unilateral primary THA due to osteoarthritis from 2010-2018.
View Article and Find Full Text PDFBackground: Exercise is recommended as first-line treatment for patients with hip osteoarthritis (OA). However, randomized controlled trials providing evidence for the optimal exercise type are lacking.
Objective: To investigate whether progressive resistance training (PRT) is superior to neuromuscular exercise (NEMEX) for improving functional performance in patients with hip OA.