Carriage, transfer and interaction of oral viruses and bacteria.

Carriage of antigens and infectious herpes simplex virus type 1 (HSV-1) and human adenovirus type 1 (Ad-1) by salivary leukocytes was compared with the antibacterial activity of oral polymorphonuclear leukocytes (PMNL) and with the spectrum of oral bacterial and fungal flora. Risk of iatrogenic infections by microbes was assessed by detecting these viruses and microbes after disinfecting dental instruments. The results indicate carriage of antigens and infectious viruses in each age group between 6 and 60 years.

Effects of the platelet-activating factor antagonist BN 52021 on anti-islet cytotoxicity of mononuclear cells and serum from type 1 (insulin-dependent) diabetic patients.

The effect of platelet-activating factor (PAF) antagonist BN 52021 (0.06-2.5 mM) on the cytotoxic activity of mononuclear cells (MNC) from newly diagnosed type 1 diabetic patients against 51Cr-labeled Langerhans islets from neonatal rats was investigated in a 6-hour cytotoxicity test.