RNase T2 restricts TLR13-mediated autoinflammation in vivo.

RNA-sensing TLRs are strategically positioned in the endolysosome to detect incoming nonself RNA. RNase T2 plays a critical role in processing long, structured RNA into short oligoribonucleotides that engage TLR7 or TLR8. In addition to its positive regulatory role, RNase T2 also restricts RNA recognition through unknown mechanisms, as patients deficient in RNase T2 suffer from neuroinflammation.

A double dissociation between semantic and spatial cognition in visual to default network pathways.

Processing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. Participants learned virtual environments consisting of buildings populated with objects, drawn from either a single semantic category or multiple categories.

Mitigating Data Leakage in a WiFi CSI Benchmark for Human Action Recognition.

Human action recognition using WiFi channel state information (CSI) has gained attention due to its non-intrusive nature and potential applications in healthcare, smart environments, and security. However, the reliability of methods developed for CSI-based action recognition is often contingent on the quality of the datasets and evaluation protocols used. In this paper, we uncovered a critical data leakage issue, which arises from improper data partitioning, in a widely used WiFi CSI benchmark dataset.

Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA production.

Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial dysfunction. However, the mechanism by which EndoG regulates mitochondrial function is not known.

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high transverse momentum (high p_{T}) hadron trigger in proton-proton and central Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV. A data-driven statistical method is used to mitigate the large uncorrelated background in central Pb-Pb collisions.

Photoproduction of K^{+}K^{-} Pairs in Ultraperipheral Collisions.

K^{+}K^{-} pairs may be produced in photonuclear collisions, either from the decays of photoproduced ϕ(1020) mesons or directly as nonresonant K^{+}K^{-} pairs. Measurements of K^{+}K^{-} photoproduction probe the couplings between the ϕ(1020) and charged kaons with photons and nuclear targets. The kaon-proton scattering occurs at energies far above those available elsewhere.

Critical Analysis of Data Leakage in WiFi CSI-Based Human Action Recognition Using CNNs.

WiFi Channel State Information (CSI)-based human action recognition using convolutional neural networks (CNNs) has emerged as a promising approach for non-intrusive activity monitoring. However, the integrity and reliability of the reported performance metrics are susceptible to data leakage, wherein information from the test set inadvertently influences the training process, leading to inflated accuracy rates. In this paper, we conduct a critical analysis of a notable IEEE Sensors Journal study on WiFi CSI-based human action recognition, uncovering instances of data leakage resulting from the absence of subject-based data partitioning.

Developments of a centimeter-level precise muometric wireless navigation system (MuWNS-V) and its first demonstration using directional information from tracking detectors.

Various positioning techniques such as Wi-Fi positioning system have been proposed to use in situations where satellite navigation is unavailable. One such system, the muometric positioning system (muPS), was invented for navigation which operates in locations where even radio waves cannot reach such as underwater or underground. muPS takes advantage of a key feature of its probe, cosmic-ray muons, which travel straightforwardly at almost a speed of light in vacuum regardless of the matter they traverse.

The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol.

Currently, a diagnosis with KRAS mutant pancreatic ductal adenocarcinoma (PDAC) means a death warrant, so finding efficient therapeutic options is a pressing issue. Here, we presented that pharmacologic ascorbate, chloroquine and resveratrol co-treatment exerted a synergistic cytotoxic effect on PDAC cell lines. The observed synergistic cytotoxicity was a general feature in all investigated cancer cell lines independent of the KRAS mutational status and seems to be independent of the autophagy inhibitory effect of chloroquine.

Mode combinability: Exploring convex combinations of permutation aligned models.

We explore element-wise convex combinations of two permutation-aligned neural network parameter vectors Θ and Θ of size d. We conduct extensive experiments by examining various distributions of such model combinations parametrized by elements of the hypercube [0,1] and its vicinity. Our findings reveal that broad regions of the hypercube form surfaces of low loss values, indicating that the notion of linear mode connectivity extends to a more general phenomenon which we call mode combinability.

Analysis of recent land management initiatives in Nicaragua from the perspective of the "ecosystem approach".

In the world there are approximately 608 million farms, of which 84% are small farms and produce 35% of the food of the world population. Training programs have been promoted by different organizations to achieve a more sustainable and efficient agricultural practice. Within this context, this article has classified a set of smallholders located in central Nicaragua with regard to how they apply Land Use Management Initiatives (LUMI).

ψ(2S) Suppression in Pb-Pb Collisions at the LHC.

The production of the ψ(2S) charmonium state was measured with ALICE in Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zero transverse momentum, at forward rapidity (2.

Policy instruments as a trigger for urban sprawl deceleration: monitoring the stability and transformations of green areas.

The socialist era postponed suburbanisation in Central and Eastern European countries. After 1990, the process became extremely intensive and transformed the compact form of cities into more decentralised and dispersed urban structures. Therefore, the study aims to identify the main trends in land-cover transformation caused by urban sprawl in peri-urban areas of three Central and Eastern European cities (NUTS 3 level: the Pest County, Bratislava Region, and Krakowski subregion).

Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo.

Incomplete reperfusion of the microvasculature ('no-reflow') after ischaemic stroke damages salvageable brain tissue. Previous ex vivo studies suggest pericytes are vulnerable to ischaemia and may exacerbate no-reflow, but the viability of pericytes and their association with no-reflow remains under-explored in vivo. Using longitudinal in vivo two-photon single-cell imaging over 7 days, we showed that 87% of pericytes constrict during cerebral ischaemia and remain constricted post reperfusion, and 50% of the pericyte population are acutely damaged.

Exploring diversity within the genus (Basidiomycota, Agaricales) in the Pannonian sandy steppe: four fascinating novel species from Hungary.

Steppe vegetation on sandy soil in Hungary has recently been revealed as one of the hot spots in Europe for the stalked puffballs (genus ). In the framework of the taxonomic revision of gasteroid fungi in Hungary, four species are described here as new to science: , , and . The study is based on detailed macro- and micromorphological investigations (including light and scanning electron microscopy), as well as a three-locus phylogeny of nrDNA ITS, nrDNA LSU and sequences.

Horizontal flow aerated constructed wetlands for municipal wastewater treatment: The influence of bed depth.

The influence of bed depth on the performance of aerated horizontal constructed wetlands was investigated at the pilot plant scale. Two horizontal flow subsurface constructed wetlands (HF) intensified units of different bed depth (HF1: 0.90 m and HF2: 0.

Measurement of the Lifetime and Λ Separation Energy of _{Λ}^{3}H.

The most precise measurements to date of the _{Λ}^{3}H lifetime τ and Λ separation energy B_{Λ} are obtained using the data sample of Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV collected by ALICE at the LHC. The _{Λ}^{3}H is reconstructed via its charged two-body mesonic decay channel (_{Λ}^{3}H→^{3}He+π^{-} and the charge-conjugate process).