Publications by authors named "Vardar M"
Article Synopsis
- The survey aimed to understand the health concerns and characteristics of long-term ovarian cancer survivors (LTS) to improve follow-up care.
- Conducted by NOGGO and shared with ENGOT and GCIG members, the anonymous survey included 68 questions and gathered responses from 1,044 LTS across 14 countries.
- Findings highlighted that LTS who survived 5-10 years reported worse health than those over 10 years, with almost half experiencing persistent symptoms like fatigue and pain, emphasizing the need for specialized long-term care.
Objective: Primary debulking surgery has been the preferred surgical route and is still considered a quality indicator for advanced ovarian cancer surgery. However, a significant number of patients are not amenable to upfront surgery. Neoadjuvant chemotherapy and interval debulking surgery may be the most suitable approach for this group.
View Article and Find Full Text PDFPrevious studies have indicated a relationship between perfectionism and social anxiety symptoms, but the mechanisms between these concepts are not well-defined yet. This study focused on the mediator role of self-compassion in the relationship between maladaptive perfectionism and social anxiety symptoms controlling self-esteem. It is hypothesized that maladaptive perfectionism would be related to lower levels of self-compassion and lower levels of self-compassion related to greater social anxiety symptoms controlling self-esteem.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to explore the significance of omental disease and assess the impact of omentectomy in managing non-endometrioid endometrial cancers (non-EEC).
- It analyzed 203 patients who had surgical treatment at a gynecologic oncology center, categorizing them based on omentectomy and omental metastasis presence to compare various clinical characteristics and survival outcomes.
- Results indicated that patients without omental metastases had significantly better 5-year disease-free survival and overall survival rates compared to those with metastases, suggesting that omentectomy might not be beneficial for non-EEC patients.
Objective: In this retrospective study, we compared the effectiveness and reliability of the third-line chemotherapies gemcitabine and liposomal doxorubicin, in patients with platinum-sensitive ovarian cancer (OC).
Patients And Methods: The retrospective study included platinum-sensitive epithelial ovarian cancer patients who had previously received paclitaxel and carboplatin therapy. Between 2013-2021, cross-matched 45 patients who received gemcitabine and 48 who received liposomal doxorubicin as third-line therapy were compared based on clinicopathological characteristics, biomarkers, and blood cancer antigen (CA) 125 levels.
Article Synopsis
- A 63-year-old woman with postmenopausal bleeding was diagnosed with epithelioid malignant melanoma after finding multiple lesions during a gynecological exam.
- She underwent a complex surgical procedure involving laparoscopic radical hysterectomy and total vaginectomy, which included extensive dissection and mobilization of surrounding tissues and organs.
- The case concludes that laparoscopic techniques can be a viable surgical option for radical procedures in certain patients with similar conditions.
We aimed to investigate whether transvaginal ultrasonography (TVUSG)-measured tumour size, pattern and location were significant predictors for lymph node metastasis in the uterus-confined endometrioid endometrial cancer (EEC) patients. A total of 213 patients with EEC were recruited and 73 of them were considered eligible and were analysed according to lymph node involvement. Tumour size, pattern and location measured by transvaginal ultrasound were recorded.
View Article and Find Full Text PDFGC-MS based metabolite fingerprinting of serous ovarian carcinoma and benign ovarian tumor.
Eur J Mass Spectrom (Chichester)
February 2022
Article Synopsis
- * Seven specific metabolites showed significant differences between ovarian cancer (OC) and benign tumor (BT) patients, with high model sensitivity (90.72% for OC vs. BT) and specificity (82.09%), indicating strong predictive capability.
- * Pathway analyses highlighted important biological processes related to the metabolites, including glutathione metabolism and aminoacyl-tRNA biosynthesis, further developing the understanding of ovarian cancer mechanisms and potential diagnostic markers.
Cardiophrenic and costophrenic lymph node resection via subxiphoid approach only.
J Turk Ger Gynecol Assoc
June 2022
Article Synopsis
- * The procedure can be done through various techniques, with the subxiphoid approach favored for costophrenic node removal while minimizing diaphragm involvement.
- * This video article demonstrates a method of resecting prepericardiac and costophrenic lymph nodes using only the subxiphoid approach, outlining the steps taken during the procedure.
This study was conducted to compare the long-term oncological outcomes of laparotomy and laparoscopic surgeries in endometrial cancer under the light of the 2016 ESMO-ESGO-ESTRO risk classification system, with particular focus on the high-intermediate- and high-risk categories. Using multicentric databases between January 2005 and January 2016, disease-free and overall survivals of 2745 endometrial cancer cases were compared according to the surgery route (laparotomy vs. laparoscopy).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates ovarian cancer patients’ responses to platinum-based treatment, focusing on differentiating those who are platinum-resistant from those who are sensitive using metabolomic analysis of urine and serum samples.
- By examining metabolites through GC-MS and applying multivariate analysis, researchers identified specific biomarkers associated with platinum resistance, such as 3,4-dihydroxyphenylacetic acid and L-arginine.
- The findings reveal significant metabolic pathways involved in these differences, highlighting the relevance of tyrosine metabolism and nitrogen metabolic pathways, which could guide alternative treatment strategies for resistant patients.
Article Synopsis
- The study aimed to evaluate treatment options and recurrence patterns for patients with grade 3 endometrioid endometrial cancer (G3-EEC) by analyzing data from 11 gynecological oncology centers over a 22-year period.
- Among 465 women analyzed, the 5-year disease-free survival (DFS) rate was 50.3%, and the overall survival (OS) rate was 57.6%, highlighting significant outcomes based on surgical success.
- The findings indicated that inadequate lymphadenectomy negatively impacted survival rates, serving as an independent prognostic factor, while optimal surgery and adequate lymphadenectomy positively correlated with better survival in advanced-stage patients.
Objectives: To evaluate the FIGO's novel classification system versus the classic terminology in patients with abnormal uterine bleeding.
Material And Methods: A retrospective study was carried out between August 2015 and September 2019 in the Health Sciences University Gazi Yaşargil Training and Research Hospital. The pathology reports of the patients were classified according to the PALM-COEIN method and were compared with classical terminology.
Article Synopsis
- This study examines high-grade endometrial adenocarcinomas, specifically Grade 3 endometrioid adenocarcinomas (G3 EAC), Type 2 endometrial carcinomas (Type 2 EC), and uterine carcinosarcomas (UCS).
- A total of 235 patients were divided into three groups based on tumor type and various factors such as age, initial symptoms, and invasion metrics were compared across groups.
- While no significant difference in overall survival was found, variations in clinical and pathological features suggest that these cancers should be treated as distinct categories despite similar survivability outcomes.
Article Synopsis
- - The study analyzed the clinicopathological features and survival rates of 302 women with uterine leiomyosarcoma (uLMS) across various stages, identifying key prognostic factors from treatments undergone between 1996-2018 in Turkey.
- - Findings revealed that the 5-year disease-free survival (DFS) and overall survival (OS) rates were 42% and 54%, respectively, with factors like lymphovascular space invasion (LVSI) and nuclear atypia negatively impacting these rates.
- - It was concluded that while lymphadenectomy improved DFS, it did not significantly affect OS, suggesting that LVSI and nuclear atypia are important prognostic indicators for patient outcomes in uLMS.
Article Synopsis
- The study aimed to explore factors related to recurrence, death, and survival rates in patients with low-grade endometrial sarcoma (LGESS) after surgery.
- It involved 124 patients, with most undergoing extensive surgeries; findings revealed some patients had lymph node metastasis, contributing to later disease recurrence or death.
- Results indicated that while lymphadenectomy improved disease-free survival, chemotherapy had a negative impact on survival outcomes, especially in patients with more advanced stages (≥II) of the disease.
Article Synopsis
- The study evaluates the Sarta-Bat approach for surgical treatment of advanced ovarian cancer involving extensive peritoneal implants.
- Thirteen patients underwent the innovative en-bloc total peritonectomy and hysterectomy-salpingo-oophorectomy procedure from February 2019 to July 2020, with all achieving complete removal of visible tumors.
- The technique is deemed feasible and effective, demonstrating acceptable complication rates while successfully addressing advanced cases of ovarian cancer.
The impact of morbid obesity on survival of endometrial cancer.
Turk J Obstet Gynecol
September 2020
Article Synopsis
- Morbid obesity (BMI ≥ 40 kg/m) is linked to endometrial cancer and poses a higher risk of death and recurrence compared to patients with lower BMI (BMI < 40 kg/m).* -
- The study reviewed data from 520 endometrial cancer patients treated between 1996 and 2018, finding significant differences in survival rates between morbidly obese and obese groups, despite similar clinical and pathological characteristics.* -
- Morbidly obese patients showed a 2.7-fold increased risk of death and a 1.7-fold increased risk of recurrence, highlighting the necessity for lifestyle modifications and management of associated health issues.*
Objective: Opioid use disorder (OpUD) is a biological and psychosocial disorder with limited treatment options. Addition of physical exercise to the pharmacological treatment has been proposed to be effective on reducing substance use and improving the quality of life. In this study we aimed to investigate the effects of a high-intensity interval training (HIIT) program on the serum levels of cortisol, insulin-like growth factor1 (IGF-1), interferon-gamma (IFN-γ), interleukin 17 (IL-17) and the clinical progress of inpatients with OpUD.
View Article and Find Full Text PDFObjectives: A considerable proportion of endometrial cancer patients are morbidly obese. Management of these cases is a serious dilemma. The aim of this study was to investigate the relevance of laparoscopic route and omission of lymphadenectomy as morbidity-reducing strategies in this special population.
View Article and Find Full Text PDFObjective: Aim of the study is to evaluate sociodemographic and clinical features that may be associated with the development of Tardive dyskinesia (TD).
Methods: 80 patients attending an outpatient psychiatry clinic in Istanbul, Turkey were divided into TD (n = 50) and control groups (CG) (n = 30). Sociodemographic and clinical data was collected through face-to-face interviews and a retrospective search of medical records.