Publications by authors named "Varalika Tyagi"
Article Synopsis
- A multicenter study examined the effects of adjunctive glucocorticoid therapy (AGT) on all-cause ICU admission and death rates among solid organ transplant recipients (SOTRs) with Pneumocystis jirovecii pneumonia (PJP) across several countries.
- The study included 172 SOTRs with an average age of 60, and found ICU admission rates at 43.4% and death rates at 20.8%.
- Results showed that AGT did not significantly lower the risk of ICU admission, death, or improve respiratory function, indicating a need to reconsider its routine use in PJP treatment for SOTRs and call for further research.
Background: Solid organ transplant (SOT) recipients are at risk for severe coronavirus disease 2019 (COVID-19), despite vaccination. Our study aimed to elucidate COVID-19 vaccine immunogenicity and evaluate adverse events such as hospitalization, rejection, and breakthrough infection in a SOT cohort.
Methods: We performed a prospective, observational study on 539 adult SOT recipients (age ≥18 years old) recruited from 7 Canadian transplant centers.