Publications by authors named "Varalakshmi P"

A novel approach to kidney tumor identification is introduced, which integrates kidney tumor classification and segmentation algorithms. The multi-faceted approach commences with the classification of kidney images, adaptly discerning between normal and tumor instances. For individuals identified as tumor-positive, a sophisticated UNet-based architecture is intricately employed to achieve precise segmentation, capturing nuanced details of both kidney and tumor regions.

View Article and Find Full Text PDF

The accurate evaluation of embryonic quality which is a key aspect in Assisted Reproductive Technology (ART) and it is crucial to ensure the success of in vitro fertilization (IVF), especially at critical developmental phases like day 3 and day 5. To increase the success rate of implantation, morphological feature-based scoring techniques are currently the mainstay of embryo evaluation. Addressing the need for enhanced accuracy and latency, our work uses advanced algorithms based on deep learning to assess microscopic images of embryos at these critical junctures.

View Article and Find Full Text PDF

Unlabelled: and like organisms (BALOs) predate on Gram-negative bacteria selectively, which holds promise as an alternate to combat against multidrug-resistant bacterial pathogens. In this study, two strains designated MPR17 and MPR18 were isolated from water samples by double-layer agar technique using as prey and investigated for their predatory potentials against six pathogenic Gram-negative, MDR and XDR bacteria. Both the BALOs preyed on all the tested bacteria including , , , , , and with different killing rates.

View Article and Find Full Text PDF

This review explicitly emphasizes the important yet unnoticed potential of macroalgae, such as seaweeds and kelps, as a powerful nature-based solution for climate change mitigation, with greater focus on the Indian Ocean seaweed diversity and efforts towards their conservation and management. Despite the IPCC's recognition of Blue Carbon ecosystems, seaweed ecosystems remain largely excluded from carbon accounting and policy frameworks. Herein, we specifically focus on the immense capacity of macroalgae globally and in the Indian Ocean coastal communities to sequester carbon, support marine biodiversity, and provide a range of ecosystem services.

View Article and Find Full Text PDF

Microalgae, owing to their efficacy and eco-friendliness, have emerged as a promising solution for mitigating the toxicity of Bisphenol A (BPA), a hazardous environmental pollutant. This current study was focused on the degradation of BPA by Coelastrella sp. M60 at various concentrations (10-50 mg/L).

View Article and Find Full Text PDF

Diabetes mellitus, a most common endocrine disorder of glucose metabolism, has become a global epidemic and poses a serious public health threat with an increased socio-economic burden. Escalating incidence of diabetes is correlated with changes in lifestyle and food habits that cause gut microbiome dysbiosis and β-cells damage, which can be addressed with dietary interventions containing probiotics. Hence, the search for probiotics of human origin with anti-diabetic, anti-AGE, and anti-ACE potentials has gained renewed interest for the effective management of diabetes and its associated complications.

View Article and Find Full Text PDF

Liposomes are unique biomolecular, capable of loading both hydrophilic and hydrophobic molecules and delivered into the biological system. Liposomes (L) coated with hyaluronic acid (HA) and chitosan (CS) carrier system was fabricated. Berberine (BER) and doxorubicin (DOX) were encapsulated to enhance drug proliferation and therapeutic effect in lung cancer cells.

View Article and Find Full Text PDF

Phycoremediation of heavy metals are gaining much attention and becoming an emerging practice for the metal removal in diverse environmental matrices. Still, the physicochemical state of metal polluted sites is often found to be complex and haphazard in nature due to the irregular discharge of wastes, that leads to the lack of conjecture on the application of microalgae for the metal bioremediation. Besides, the foresaid issues might be eventually ended up with futile effect to the polluted site.

View Article and Find Full Text PDF

Parkinson's disease is a nervous system abnormality marked by decreased dopamine levels in the brain. Parkinson's disease inhibits one's ability to move. Speech difficulty, changes in movement and handwriting, and other symptoms are common with Parkinson's disease.

View Article and Find Full Text PDF

In the present study, biomass from the Chromolaena odorata plant's stem was activated using sulfuric acid to adsorb crystal violet (CV) dye. The adsorption operation of CV dye was studied considering the effect of variables like pH, initial dye concentration, time, adsorbent dosage, and temperature. The pseudo-second-order equation best fitted the kinetic study.

View Article and Find Full Text PDF

Novel magnetic microcomposites consisting of graphene oxide and iron oxide was synthesized to immobilize metabolically versatile Paracoccus sp. MKU1 and Leucobacter sp. AA7 and tested for the simultaneous adsorption and enhanced biological detoxification of hexavalent chromium (Cr(VI)) from tannery wastewater.

View Article and Find Full Text PDF

A cheap cultivation of microalgae greatly reduces the biodiesel production cost. Subsequently in this study, citric acid and effluents from sugar and tannery industries were used as the nutritional supplements for the improvement of biomass and TAG production in Phaeodactylum tricornutum using two-step cultivation. When compared to control (media without supplementation), a considerable increase in biomass and chlorophyll a was obtained with citric acid (CA) and sugar industry effluent (SIE) supplemented media.

View Article and Find Full Text PDF

The tremendous shift in technology has led to many unconnected things getting interconnected via IoT. IoT is one of the major modes of collecting data from various networked resources and other connected devices. The broad range of IoT, with its huge heterogeneity in handling data, addresses many challenges in the realm of healthcare.

View Article and Find Full Text PDF

A need to enhance healthcare sector amidst pandemic arises. Many technological developments in Artificial Intelligence (AI) are being constantly leveraged in different fields of healthcare. One such advancement, Federated Learning(FL) has acquired recognition primarily due to its decentralized, collaborative nature of building AI models.

View Article and Find Full Text PDF

Over the past year, owing to the emergent demand for the search for potential COVID-19 therapeutics, identifying alternative candidates from biological sources is one of the sustainable ways to reinforce the drug discovery process. Marine macroalgae have numerous advantages because of the richest availability of underexploited bioactive compounds. Polyphenolic compounds like phlorotannins obtained from brown macroalgae are reported as proven antiviral and immunostimulatory agents.

View Article and Find Full Text PDF

Microalgae are the most attractive renewable energy sources for the production of biofuels because of their luxurious growth and lipid accumulation ability in diverse nutritional conditions. In the present study, Desmodesmus sp. VV2, an indigenous microalga, was evaluated for its biodiesel potential using Response Surface Methodology (RSM) to improve the lipid accumulation with the combination of nutrients stress NaNO starvation, CaCl depletion, and supplementation of magnesium oxide nanoparticles (MgO).

View Article and Find Full Text PDF

Marine macroalgae offer an endurable source of renewable biomass, which do not require cultivable area, fertilizers for cultivation for bioproducts production. In this study, marine brown macroalga Padina tetrastromatica as an alternate sustainable feedstock for the production of liquid fuels. Padina tetrastromatica biomass was collected from Mandapam; the coastal region of Rameswaram, Tamil Nadu, India.

View Article and Find Full Text PDF

Cis, -muconic acid (ccMA) is known for its industrial importance as a precursor for the synthesis of several biopolymers. Catechol 1,2-dioxygenase (C12O) is involved in aromatic compounds catabolism and ccMA synthesis in a greener and cleaner way. This is the first study on gene from a metabolically versatile sp.

View Article and Find Full Text PDF
Article Synopsis
  • Mutations in the ALDH3A2 gene are responsible for Sjögren-Larsson syndrome (SLS), a condition characterized by neurological symptoms and skin issues, due to a lack of fatty aldehyde dehydrogenase (FALDH).
  • The study identified five new harmful mutations in ALDH3A2 among six Indian cases, highlighting unusual neurological features like "intrinsic-minus-claw hands" in two siblings, and examined their impact on disease diversity and symptoms.
  • Research showed that these mutations disrupt critical functions of the FALDH enzyme, leading to reduced activity and diverse skin conditions such as hyperplasia and abnormal lipid vacuoles, contributing to better diagnosis and treatment strategies
View Article and Find Full Text PDF
Article Synopsis
  • The COVID-19 pandemic has caused a global crisis, prompting urgent research for new antiviral treatments as existing options are limited and the SARS-CoV-2 virus spreads rapidly.
  • This study investigates the potential of marine algal compounds to inhibit the virus's entry and replication using molecular docking analysis, focusing on key targets in the virus's lifecycle like spike glycoprotein and 3-chymotrypsin-like protease.
  • Results highlight several marine algal compounds, such as κ-carrageenan and eckol, showing promising binding scores against SARS-CoV-2 targets, suggesting their potential as effective treatments after further testing and validation.
View Article and Find Full Text PDF

In response to the coronavirus (COVID-19) pandemic, Government and public health authorities around the world are developing contact tracing apps as a way to trace and slow the unfold of the virus. There is major divergence among nations, however, between a "privacy-first" approach that protects citizens' information at the price of very restricted access for public health authorities and a "data-first" approach that stores massive amounts of knowledge that, whereas of immeasurable price to epidemiologists. Contact tracing apps work by gathering information from people who have tested positive for the virus and so locating and notifying individuals with whom those people are in shut contact, oftentimes by use of GPS, Bluetooth, or wireless technology.

View Article and Find Full Text PDF