Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta).

Potential deleterious behavioral effects of the anticholinergics biperiden and scopolamine were examined via the performance of rhesus monkeys on a serial-probe recognition (SPR) procedure. On each trial, six unique stimuli (list items) were presented sequentially followed by a choice phase. In the choice phase, two stimuli were presented, a standard or 'default' stimulus (a white rectangle) and a 'probe' stimulus that differed with each choice trial.

Chronic T cell lymphocytosis: a review of 21 cases.

Twenty-one patients are described with a proliferation of morphologically mature T lymphocytes. The clinical course was chronic in most, and splenic enlargement the main clinical finding; skin involvement and lymphadenopathy were rare. The mean lymphocyte count at presentation was 8 X 10(9)/1 (range 0.

Disaccharidases in coeliac disease.

In 30 children presenting with complaints characteristic of malabsorption in whom congenital enzyme deficiency could be excluded, determination of the enzymes lactase, saccharase and maltase was performed in the tissue sample obtained by jejunal biopsy; histology was also carried out in all cases. In 23 cases the diagnosis of coeliac disease could subsequently be confirmed, in the other 7 cases the diagnosis could neither be rejected nor established with certainty. All three enzymes had a decreased activity in cases displaying subtotal or total villous atrophy, the most sensitive among them being lactase: in 69% of cases no lactase activity could be shown while saccharase and maltase were absent in 29 respectively 4% of the cases.

Screening of psychiatric patients for hypovitaminosis B12.

Vitamin B(12) assays and inspection of peripheral blood films performed on 1,004 consecutive new patients over the age of 50 admitted to mental hospital led to the discovery of pernicious anaemia in only two cases. It is concluded that routine vitamin B(12) assays are justified only when fully-automated techniques have become available.

Correlation of peripheral white cell and bone marrow changes with folate levels in pregnancy and their clinical significance.

Two hundred and thirty-eight ;megaloblastic' pregnancies are reviewed. Bone-marrow aspiration was performed in every case. Serum folate estimations were strongly suggestive of folic acid deficiency in only 34% of cases.