Publications by authors named "Vanshika Sharma"

The increasing threat of antibiotic resistance and shrinking treatment options for infections have pushed mankind into a difficult position. The looming threat of the return of the pre-antibiotic era has caused a sense of urgency to protect and conserve the potency of antibiotic therapy. One of the perverse effects of antibiotic resistance is the dissemination of its causative agents from non-clinically important strains to clinically important strains and vice versa.

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  • Medicinal plants are recognized for their antimicrobial properties, particularly through essential oils that inhibit key microbial targets and biofilm formation.
  • In a study, essential oil from a specific plant was analyzed, leading to the identification of eleven compounds, with γ-elemene and caryophyllene showing strong interactions with biofilm-related target proteins CrtM and SarA.
  • These compounds exhibited non-toxicity and significant binding affinities during molecular dynamic simulations, indicating their potential as biofilm inhibitors.
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  • A new reversible fluorescent-colorimetric receptor (L) has been created to detect lead (Pb) in water, showing rapid and selective responses.
  • The receptor demonstrates high sensitivity with detection limits of 0.53 nM for fluorescence and 1.0 nM for colorimetric methods, outperforming previous alternatives.
  • L effectively identifies Pb across a pH range of 4-8 and has been successfully tested in solutions containing proteins and real samples, with its structure optimized through various scientific methods.
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In this study, we report a new syringe aldehyde-derived hydrazinyl-imidazole based fluorescent sensor (L) for sensitive detection of different inorganic quenchers (halide ions, bicarbonate ion, sulphide ion and transition metal ions). The chromophore (L) was obtained in good yield by the 1:1 condensation reaction of 2-hydrazino-4,5-dihydroimidazole hydrobromide and 4-hydroxy-3,5-dimethoxy benzaldehyde. L exhibited strong fluorescence in the visible region (around 380 nm) and its interaction with different quenchers was studied in details via fluorescence technique.

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Herein, we have reported a novel quinazolin-based Schiff base chemosensor ()-2-benzamido-'-(1-(pyridin-2-yl)ethylidene)benzohydrazide (L). L has been designed, synthesised and characterised by H-NMR, IR spectroscopy, ESI-MS spectrometry and theoretical studies. The receptor showed appreciable colorimetric shift for both Ni and Zn ions and fluorometric "" response in presence of only Zn ion.

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Background: Urine collection devices (UCDs) are being marketed and used in clinical settings to reduce urine sample contamination, despite inadequate supporting evidence.

Aim: To determine whether UCDs, compared with standardised instructions for urine sample collection, reduce the proportion of contaminated samples.

Design And Setting: Single-blind randomised controlled trial in general practices in England and Wales.

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Article Synopsis
  • Chronic kidney disease (CKD) is diagnosed using the estimated glomerular filtration rate (eGFR) and urinary albumin:creatinine ratio (ACR), with eGFR calculated from serum creatinine levels using two different equations.
  • A study analyzed data from 485 participants over 60 to compare the effectiveness of one vs. two eGFR/ACR measurements and how different equations affect CKD diagnosis.
  • Results showed that using only one test significantly overestimated CKD prevalence, and switching from the MDRD to the CKD-EPI equation could lead to reclassification of some patients, affirming the importance of using two measurements for accurate CKD diagnosis.
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Objectives: To assess the performance of circulating vascular endothelial growth factor (VEGF) levels as a tool for diagnosing giant cell arteritis (GCA) in a cohort of patients referred for assessment of suspected GCA.

Methods: We selected 298 patients recruited to the multicentre study Temporal Artery Biopsy versus Ultrasound in diagnosis of suspected GCA (TABUL). In a random subset of 26 biopsy-proven GCA cases and 26 controls, serum from weeks 0, 2 and 26 was analysed for VEGF concentration using ELISA.

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