A multi-objective optimization framework through genetic algorithm for hyperthermia-mediated drug delivery.

This study presents an approach to the multi-objective optimization of hyperthermia-mediated drug delivery using thermo-sensitive liposomes (TSLs) for the treatment of hepatocellular carcinoma. The research focuses on addressing the non-optimal coupling methods that combine thermal treatments and chemotherapy by employing a Multi-Objective Genetic Algorithm (MOGA) optimization process, in order to identify the right combination of design variables to achieve better treatment outcomes. The proposed model integrates Computational Fluid Dynamics (CFD) analysis using the Pennes' Bioheat equation for tissue heating and a convection-diffusion model for drug delivery.

Microwave ablation modeling with AMICA antenna: Validation by means a numerical analysis.

Background And Objectives: Percutaneous microwave thermal ablation is based on electromagnetic waves that generate dielectric heating, and it is widely recognized as one of the mostly used techniques for tumor treatment. The aim of this work is to validate a predictive model capable of providing physicians with guidelines to be used during thermal ablation procedures avoiding collateral damage.

Methods: A finite element commercial software, COMSOL Multiphysics, is employed to implement a tuning-parameter approach.

Mathematical modeling of microwave liver ablation with a variable-porosity medium approach.

Background And Objectives: Thermal ablation of tumors plays a key role to fight cancer, since it is a minimally invasive treatment which involves some advantages compared to surgery and chemotherapy, such as shorter hospital stays and consequently lower costs, along with minor side effects. In this context, computational modeling of heat transfer during thermal ablation is relevant to accurately predict the obtained ablation zone in order to avoid tumor recurrence risk caused by incomplete ablation, and the same time to save the surrounding healthy tissue. The aim of this work is to develop a more realistic porous media-based mathematical model to simulate a microwave thermal ablation (MWA) of an in vivo liver tumor surrounded by healthy tissue.

Pennes' bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation.

The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes' equation and two porous media-based models, i.e.

Numerical analysis of the pulsating heat source effects in a tumor tissue.

Background And Objectives: Hyperthermia treatment is nowadays recognized as the fourth additional cancer therapy technique following surgery, chemotherapy, and radiation; it is a minimally or non-invasive technique which involves fewer complications, a shorter hospital stay, and fewer costs. In this paper, pulsating heat effects on heat transfer in a tumor tissue under hyperthermia are analyzed. The objective of the paper is to find and quantify the advantages of pulsatile heat protocols under different periodical heating schemes and for different tissue morphologies.

The design of safe classrooms of educational buildings for facing contagions and transmission of diseases: A novel approach combining audits, calibrated energy models, building performance (BPS) and computational fluid dynamic (CFD) simulations.

The proposed investigation is aimed at providing useful suggestions and guidelines for the renovation of educational buildings, in order to do University classrooms safe and sustainable indoor places, with respect to the 2020 SARS-CoV-2 global pandemic. Classrooms and common spaces have to be thought again, for a new "in-presence" life, after the recent worldwide emergency following the spring 2020 pandemic diffusion of COVID-19. In this paper, starting from a real case study, and thus the architectural and technological refurbishment of an Italian University building (Campobasso, South Italy, cold climate), with the aims of improving the classrooms' quality and safety, a comprehensive approach for the retrofit design is proposed.

Modeling Heat Transfer in Tumors: A Review of Thermal Therapies.

It is quite challenging to describe heat transfer phenomena in living systems because of the involved phenomena complexity. Indeed, thermal conduction and convection in tissues, blood perfusion, heat generation due to metabolism, complex vascular structure, changing of tissue properties depending on various conditions, are some of the features that make hard to obtain an accurate knowledge of heat transfer in living systems for all the clinical situations. This theme has a key role to predict accurately the temperature distribution in tissues, especially during biomedical applications, such as hyperthermia treatment of cancer, in which tumoral cells have to be destroyed and at the same time the surrounding healthy tissue has to be preserved.