Publications by authors named "Vanoirbeek J"
Background: Antineoplastic agents are hazardous drugs used in cancer treatment and consequently can be present at the workplace (e.g. hospital), but also in a home-setting in case of treatment at home.
View Article and Find Full Text PDF5-Fluorouracil (5-FU) is a well-known cytostatic drug, which is often used in cancer treatments. Yet, it is also a very dangerous compound for people who are occupationally exposed to it for a long time, such as pharmacy employees, nurses and cleaning staff. We aimed to improve and implement a LC-MS/MS method for 5-FU quantification on surface contamination samples collected with swabs in a pharmacy department and outpatient nursing station of a university hospital.
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- Rising plastic use has led to microplastic contamination, and Raman spectroscopy is a key method for identifying these particles, though it struggles with interference from pigments and additives in colored samples.
- This study evaluates how effective various oxidative treatments (like HO, sodium hypochlorite, and Fenton's reagent) are at reducing these interferences and improving the accuracy of Raman spectroscopy in identifying colored microplastics.
- Findings indicate that colorants, especially red pigments, can significantly hinder polymer identification, and current treatment methods do not effectively enhance accuracy; thus, improved strategies and technology are needed for better results.
Article Synopsis
- A variety of commonly used cancer drugs like cyclophosphamide, daunorubicin, epirubicin, doxorubicin, and paclitaxel lack simultaneous measurement methods for their levels and metabolites in human plasma.
- The research developed a sensitive method using solid phase extraction, UPLC, and tandem mass spectrometry, validating it based on various criteria such as sensitivity and precision.
- The method was successfully tested on plasma samples from pregnant cancer patients, detecting cyclophosphamide concentrations, indicating its practical application for monitoring drug exposure.
Cytotoxicity assessment of eluates from vacuum-forming thermoplastics.
Clin Oral Investig
October 2024
Objectives: This study aimed to evaluate possible cytotoxic effects of thermoplastic materials commonly used for occlusal splints and orthodontic appliances.
Methods: Seven thermoplastics were included: three variants of the Essix sheets (C+, Plus, and Tray Rite; Dentsply Sirona), three thermoplastics (Bleach Heavy, Splint, and X-Heavy; Cavex Holland) and Invisalign (Align Technology). Cylindrical specimens (n = 24; 10 mm diameter) were incubated in cell culture medium for 24 h and 14 days.
The ability of air pollution to induce acute exacerbation of asthma is well documented. However, the ability of ozone (O), the most reactive gaseous component of air pollution, to function as a modulator during sensitization is not well established. C57BL/6 J male mice were intranasally sensitized to house dust mite (HDM) (40 μg/kg) for 3 weeks on alternate days in parallel with once-a-week O exposure (1 ppm).
View Article and Find Full Text PDFExposure to environmental pollutants such as diesel exhaust particles (DEP) increases the risk of respiratory disease exacerbation. However, the possible effects of these particles on the general population remain poorly understood. The present study aimed to assess the immunomodulatory and inflammatory effects of the inhalation of DEP in a model of healthy mice undergoing short-, mid- and long-term exposure.
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- Obesity is linked to various health issues, including non-alcoholic fatty liver disease and asthma, but there is limited research on how exercise and diet affect these conditions in the context of obesity.
- In an experiment with mice, those on a high-fat diet were split into two groups: one continued on the high-fat diet while the other switched to a normal diet, with half of each group doing exercise.
- The results showed that while combining diet and exercise reduced liver fat and damage, it increased airway inflammation and sensitivity in mice, highlighting a complex relationship between weight management and respiratory health.
Objectives: Resin composites may release bisphenol A (BPA) due to impurities present in the monomers. However, there is a lack of knowledge regarding the leaching characteristics of BPA from resin composites. Therefore, experimental resin composites were prepared with known amounts of BPA.
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- - The study focuses on chronic rejection in lung transplantation, exploring its nature, timing, and location, challenging the idea that it primarily affects airways.
- - Researchers conducted experiments on mice, sacrificing them at different time points post-transplantation to analyze the progression of chronic rejection through histology and advanced imaging techniques.
- - Findings revealed that chronic rejection begins with innate inflammation around small arteries and evolves through various stages, ultimately affecting bronchioles, suggesting that the process may not align with current beliefs about Chronic Lung Allograft Dysfunction (CLAD).
Purpose: To assess elution from direct composite materials for provisional restorations and compare them with elution from direct restorative composites for permanent restorations.
Methods: Two dual-cure (Integrity Multi-Cure and Tempsmart DC) and two self-curing composites (Protemp 4 and Structur 3) were used, with Essentia serving as a reference. Cylindrical specimens (n=20) were cured according to the manufacturer's instructions; the dual-cure materials were prepared in both self- and dual-curing modes.
Article Synopsis
- Man-made products are increasing the risk of diseases, and there's a call for better safety rules to protect people.
- The REACH Committee wants changes to rules so they use modern science and make decisions faster about chemicals before and after they are sold.
- Suggestions include better testing for harmful effects and a "no data, no market" rule to stop dangerous chemicals from being sold.
Background: Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects.
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- Plasmodium parasites cause malaria, leading to over 200 million cases and 600,000 deaths annually, with complications like malaria-associated acute respiratory distress syndrome (MA-ARDS) contributing significantly to mortality despite effective antimalarial drugs.* -
- A study on infected mice showed that treatment with antimalarial drugs post-symptom onset resulted in 80% survival, while alterations in lung function and inflammation were observed during infection and recovery.* -
- The research highlights important changes in inflammatory pathways and endothelial cell behavior during the resolution phase of MA-ARDS, suggesting potential new therapeutic strategies to enhance recovery after parasite elimination.*
Background: In low- and middle-income countries countries, millions of deaths occur annually from household air pollution (HAP), pulmonary tuberculosis (PTB), and HIV-infection. However, it is unknown whether HAP influences PTB risk among people living with HIV-infection.
Methods: We conducted a case-control study among 1,277 HIV-infected adults in Bukavu, eastern Democratic Republic of Congo (February 2018 - March 2019).
The implementation of nanotechnology in pulmonary delivery systems might result in better and more specific therapy. Therefore, a nano-sized drug carrier should be toxicologically inert and not induce adverse effects. We aimed to investigate the responses of a polymer nano drug carrier, a lysine poly-hydroxyethyl methacrylate nanoparticle (NP) [Lys-p(HEMA)], loaded with formoterol, both in vitro and in vivo in an ovalbumin (OVA) asthma model.
View Article and Find Full Text PDFBackground: In developing countries, millions of deaths occur annually from household air pollution (HAP), pulmonary tuberculosis (PTB), and HIV-infection. However, it is unknown whether HAP influences PTB risk among people living with HIV-infection.
Methods: We conducted a case-control study among 1,277 HIV-infected adults in Bukavu, eastern Democratic Republic of Congo (February 2018 - March 2019).
Background: Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects.
View Article and Find Full Text PDFFrequent Allergic Sensitization to Farmed Edible Insects in Exposed Employees.
J Allergy Clin Immunol Pract
December 2023
Article Synopsis
- * Testing revealed that a majority had positive reactions for insect allergens, and many displayed bronchial hyperreactivity or had co-sensitization with house dust mites.
- * The findings highlight the need for preventive measures and ongoing health surveillance in the growing insect production industry to protect employee health.
Article Synopsis
- * This study created the first mouse model specifically to study RSV infection in a DS context using Ts65Dn mice, allowing researchers to monitor viral replication using bioluminescence imaging.
- * Results showed similar viral loads in Ts65Dn and normal mice, but significant immune system differences were observed, such as reduced CD8+ T cells and B-cells in the DS mice, highlighting the model's potential for future research on RSV and immune responses in individuals with DS.
Due to the close interaction of lung morphology and functions, repeatable measurements of pulmonary function during longitudinal studies on lung pathophysiology and treatment efficacy have been a great area of interest for lung researchers. Spirometry, as a simple and quick procedure that depends on the maximal inspiration of the patient, is the most common lung function test in clinics that measures lung volumes against time. Similarly, in the preclinical area, plethysmography techniques offer lung functional parameters related to lung volumes.
View Article and Find Full Text PDFThe atmosphere is pervasively polluted by microplastics and nano plastics (M/NPs) released into indoor and outdoor areas. However, various methodologies and their limitations along with non-standardization make the comparison of information concerning their prevalence difficult. Such diversity in techniques greatly limits the interpretation of results.
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- The text refers to a correction made to a specific article with the DOI: 10.3389/fimmu.2022.849155, indicating that there may have been an error or oversight in the original publication.
- The correction is important for maintaining the accuracy and integrity of the scientific record related to the research presented in the article.
- Readers looking for the corrected information or updates should refer to the corrected version of the article through its DOI link.