cytotoxicity evaluation of thiourea derivatives bearing constituent against HK-1 cell lines.

In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea ( chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that halogens at position of showed promising activity against HK-1 cells (IC value ≤15 µM) in comparison to cisplatin, a positive cytotoxic drug (IC value =8.