Publications by authors named "Vannappilakkal Sreelaya"

Hydrazine (NH) and hydrogen sulfide (HS) are environmental contaminants that adversely affect human health. Fluorescence-based detection methods for these analytes utilize their nucleophilicity and reducing ability. Therefore, fluorescent sensors capable of detecting and distinguishing hydrazine and HS are highly beneficial.

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Picric acid (PA) is an important industrial feedstock and hence the release of industrial effluents without proper remediation results in its buildup in soil and water bodies. The adverse effects of PA accumulation in living beings necessitate the development of efficient methods for its detection and quantification. Herein, we describe pyrene-based fluorescent sensors for PA, where pyrene is appended with electron-withdrawing groups, malononitrile, and 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene) malononitrile (DCDHF).

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In this study, Enzalutamide (ENZ) loaded Poly Lactic--Glycolic Acid (PLGA) nanoparticles coated with polysarcosine and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared using a three-step modified nanoprecipitation method combined with self-assembly. A three-factor, three-level Box-Behnken design was implemented with Design-Expert® software to evaluate the impact of three independent variables on particle size, zeta potential, and percent entrapment efficiency through a numeric optimization approach. The results were corroborated with ANOVA analysis, regression equations, and response surface plots.

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For more effective chemotherapy and targeted treatment of colorectal cancer, this study seeks to develop chitosan (CH)-human serum albumin (HAS)-D-α-tocopheryl polyethylene glycol 1000 (TPGS) nanoparticles (BOS-CH-HSA-TPGS-NPs) coated with Bosutinib (BOS). Nuclear magnetic resonance (NMR) indicated that chitosan's structure was modified by carbodiimide coupling with HSA. We used a Box-Behnken design to find the ideal region for particle size, zeta potential, and entrapment efficiency, eventually emerging at a formulation with these values: 187.

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To develop hyaluronic acid (HA)-coated poly-lactic-co-glycolic acid (PLGA)-polysarcosine (PSAR) coupled sorafenib tosylate (SF) polymeric nanoparticles for targeted colon cancer therapy. PLGA-PSAR shells were encapsulated with SF via nanoprecipitation. Interactions were examined with transmission electron microscopy, revealing formulation component interactions.

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Cubosomes are a kind of nanoparticle that is distinct from solid particles in that they are liquid crystalline particles formed by self-assembly of a certain surfactant with a current water ratio. Their unique properties as a result of their microstructure are useful in practical applications. Cubosomes, specifically lyotropic nonlamellar liquid crystalline nanoparticles (LCNs) have gained acceptance as a medication delivery strategy for cancer and other disorders.

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Vesicular delivery systems are a kind of drug delivery system that is gaining popularity due to its sustained release nature. This article was designed to understand the characteristics of a drug carrier called multivesicular liposomes, which have the potential to be the future of sustainedrelease drug delivery systems. Multivesicular liposomes have a honeycomb-like structure made up of non-concentric aqueous polyhedral compartments separated by continuous lipid membranes.

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