Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.

Background: Standard treatment for patients with newly diagnosed glioblastoma includes surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy (TMZ/RT→TMZ). The proteasome has long been considered a promising therapeutic target because of its role as a central biological hub in tumor cells. Marizomib is a novel pan-proteasome inhibitor that crosses the blood-brain barrier.

Prognostic significance of therapy-induced myelosuppression in newly diagnosed glioblastoma.

Background: Myelosuppression is the major toxicity encountered during temozolomide chemoradiotherapy for newly diagnosed glioblastoma.

Methods: We assessed the association of myelosuppression (neutropenia, thrombocytopenia, anemia, and lymphopenia) during temozolomide chemoradiotherapy alone or in combination with experimental agents with progression-free survival (PFS) or overall survival (OS) in 2073 patients with newly diagnosed glioblastoma enrolled into five clinical trials: CENTRIC, CORE, EORTC 26082, AVAglio, and EORTC 26981. A landmark Cox model was used.

Development of Randomized Trials in Adults with Medulloblastoma-The Example of EORTC 1634-BTG/NOA-23.

Medulloblastoma is a rare brain malignancy. Patients after puberty are rare and bear an intermediate prognosis. Standard treatment consists of maximal resection plus radio-chemotherapy.

Analysis of mineral oil in food: results of a Belgian market survey.

Recently, migration of mineral oil components from food contact materials into various foods has been reported. The analysis of mineral oil in food is complicated since it consists of mineral oil saturated hydrocarbons (MOSH) comprising a complex mixture of linear, branched and cyclic compounds and variable amounts of mineral oil aromatic hydrocarbons (MOAH), mainly alkylated. Both MOSH and MOAH form 'humps' of unresolved peaks in the chromatograms with the same range of volatility.

Histologic and microbiologic findings in the fallopian tubes of IUD users.

Non-microbial inflammatory changes are more frequent in the oviducts of IUD users than in those of former users and never users. No correlation was found between the incidence of non-microbial tubal inflammation and the interval between IUD use and tubal sterilization, pelvic inflammation and surgery, and parity. Inflammatory response was more common among women using copper devices than among those wearing a non-copper IUD.

A randomized study of two cups for vacuum extraction.

O'Neil designed a set of suction cups which, because of more efficient lateral pull and greater maneuverability, were claimed to be more efficient and perinatally safer than the Malmström model. These claims were checked by comparing the two instruments in a randomized controlled trial comprising 410 attempted elective extractions. The two instrument groups were comparable at entry and the operators had a similar degree of experience, the sole inter-group difference being the 0.

Cytomegalovirus hemopericarditis. Report of 1 case with histologic confirmation.

An otherwise healthy woman presented cytomegalovirus (CMV) infection with an haemorrhagic pericardial effusion. This disease was successfully treated by a pericardial window and corticoid administration. CMV antibody titers and observation of CMV inclusions in the pericardial biopsy (fig.