Publications by authors named "Vanius Vinicius Dipe"
Article Synopsis
- Leucaena leucocephala is a plant used for food that contains a toxic compound called L-mimosine, which has potential cancer treatment properties due to its ability to chelate metal ions.
- This study aimed to understand how L-mimosine affects immune responses in Wistar rats by administering varying doses (25, 40, and 60 mg/kg) over 28 days.
- Results showed no signs of toxicity, but a decrease in T-dependent immune responses at the highest dose and enhanced phagocytosis by macrophages at medium to high doses, indicating that while L-mimosine inhibited certain immune functions, it did not compromise macrophage activity.
Article Synopsis
- * This study examined the toxicity of L-mimosine in adult Wistar rats, administering varying doses over 28 days, and assessed various health parameters including weight gain, feed intake, hormonal levels, and organ health.
- * Findings revealed no significant clinical toxicity, but histopathological analysis indicated thyroid lesions and hormonal disruptions, including lowered testosterone levels, which suggest that L-mimosine may impair male reproductive function.
