Correlation of the Changing Trends of ScvO, Serum Lactate, Standard Base Excess and Anion Gap in Patients with Severe Sepsis and Septic Shock Managed by Early Goal Directed Therapy (EGDT): A Prospective Observational Study.

Background: To observe the correlation of central venous oxygen saturation (ScvO), serum lactate, standard base excess (SBE), and anion gap (AG) in septic and septic shock patients resuscitated with early goal-directed therapy (EGDT).

Materials And Methods: A review was made of 130 severe septic shock patients (15-65 years) according to the consensus conference criteria admitted in intensive care unit. Blood samples were obtained from arterial and central venous line for ScvO serum lactate, SBE, and AG on admission and after achieving all aims of EGDT i.

A comparative study of sedo-analgesic effect of dexmedetomidine and dexmedetomidine with ketamine in postoperative mechanically ventilated patients.

Background And Aims: To compare the sedoanalgesic effects of dexmedetomidine alone or with combination of ketamine.

Material And Methods: After getting ethical approval and informed patient consent, 60 adult surgical patients, were randomly divided into two groups. Group KD ( = 30); received dexmedotomidine 0.

Diagnostic Accuracy of Various Biomarkers of Sepsis (Serum Pro-Calcitonin, High-Sensitivity C-reactive Protein, and C-reactive Protein) and Band Cell Percentage in Critically lll Patients: A Prospective, Observational, Cohort Study.

Background: Despite the advances in medical sciences, the morbidity and mortality due to sepsis in critically ill medical or surgical patients remains high, hence the need for an early and accurate diagnosis. In the current armamentarium, we have various biomarkers such as procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), CRP, and band cell percentage for an early clue.

Aims: This study explores the accuracy of these markers in distinguishing sepsis from systemic inflammatory response syndrome (SIRS) and their correlation with sequential organ failure assessment (SOFA) scoring in critically ill patients.