Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca/CaMKII/pannexin 1-dependent signaling.

Pannexin1 (Panx1) is a glycoprotein, ubiquitously expressed throughout vertebrate tissues. In the cell membrane, it forms non-selective hemichannels (Panx1 HCs) that allow the release of ATP. This extracellular ATP triggers purinergic signaling relevant to the immune responses to pathogens, including viruses.