Suppression of Toll-like receptor 2-mediated proinflammatory responses by protein Rv3529c.

Microorganisms are known to devise various strategies to thwart protective responses by the host. One such strategy is to incorporate sequences and domains in their genes/proteins that have similarity to various domains of the host proteins. In this study, we report that protein Rv3529c exhibits significant similarity to the death domain of the TLR pathway adaptor protein MyD88.