Publications by authors named "Vanessa da Rocha"
The 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) shows promise for its antinociceptive and anti-inflammatory properties. Here, we explored the structure-activity relationship of 4-PSQ and its analogues: 7-chloro-4-[(4-fluorophenyl) selanyl]quinoline (a), 7-chloro-4-{[3-trifluoromethyl)phenyl] selanyl} quinoline (b), 4-((3,5-Bis(trifluoromethyl)phenyl) selanyl-7-chloroquinoline (c), 7-chloro-4-[(2,4,6-trimethyl)selanyl]quinolinic acid (d) and 7-chloroquinoline-4-selenium acid (e) in models of acute inflammation and chemical, thermal and mechanical nociception in mice, alongside in silico analysis. Compounds a (-F), b (-CF), c (-Bis-CF), d (-CH), e (-OOH), and 4-PSQ exhibited antinociceptive effects in chemical and thermal nociception models, except d (-CH) and e (-OOH) in the hot plate test.
View Article and Find Full Text PDFThis study aimed to elucidate vincristine (VCR)-induced peripheral neuropathy in aged rats, a poorly understood neurotoxicity. Both young and old Wistar rats were administered VCR (0.1 mg/kg, intraperitoneally (i.
View Article and Find Full Text PDFArticle Synopsis
- - Goiter, or enlargement of the thyroid gland, was observed in Brazilian basslets, a type of marine ornamental fish, in a research laboratory from 2016 to 2023, showing signs of tumor-like growths affecting feeding and respiration.
- - Around 20 adult fish developed these growths in the pharyngeal cavity and gill arches, resulting in severe health issues and eventual death within months after the growth appeared.
- - Histological analysis showed significant changes in thyroid cells, marking the first report of goiter in this species, and researchers recommend maintaining low nitrate levels and regular monitoring of iodine in water until more is known about the condition.
Association between nutrition intake and muscle mass in adult inpatients receiving nutrition support: A prospective cohort study.
JPEN J Parenter Enteral Nutr
May 2024
Objective: The present study aimed to evaluate the association between muscle mass variation, estimated by different equations, during hospitalization with the energy and protein intake and clinical and nutrition outcomes of patients using nutrition support.
Methods: A prospective observational study with patients older than 18 years in use of enteral and/or parenteral nutrition therapy and monitored by the Nutritional Therapy Committee between December 14, 2021, and December 14, 2022. Data were collected from the electronic records and were applied in 11 equations to estimate the four different portions of muscle mass of patients receiving nutrition support at the beginning and the end of hospitalization.
Objective: to evaluate the impairment of social and emotional domains of hospitalized patients undergoing hematopoietic stem cells transplantation.
Method: an observational, longitudinal study with 25 participants evaluated in the period of pre-transplant, pancytopenia and pre-hospital discharge between September 2013 and September 2014, in a reference hospital for this treatment modality in Brazil. Two international instruments were used, both of which translated and adapted to Portuguese (Brazil): Quality of Life Questionnaire-Core 30 and Functional Assessment Cancer Therapy - Bone Marrow Transplantation.