The ARC2 response in requires the global regulatory genes and .

ARC2 is a synthetic compound, related in structure and mechanism to the antibiotic triclosan, that activates the production of many specialized metabolites in the genus of bacteria. In this work, we demonstrate that the addition of ARC2 to cultures results in considerable alterations in overall gene expression including most notably the specialized metabolic genes. Using actinorhodin production as a model system, we show that the effect of ARC2 depends on the pleiotropic regulators and but not .