Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.

Trk (NTRK) receptor and NTRK gene fusions are oncogenic drivers of a wide variety of tumors. Although Trk receptors are typically activated at the cell surface, signaling of constitutive active Trk and diverse intracellular NTRK fusion oncogenes is barely investigated. Here, we show that a high intracellular abundance is sufficient for neurotrophin-independent, constitutive activation of TrkB kinase domains.

Synthetic methylotrophic yeasts for the sustainable fuel and chemical production.

Global energy-related emissions, in particular carbon dioxide, are rapidly increasing. Without immediate and strong reductions across all sectors, limiting global warming to 1.5 °C and thus mitigating climate change is beyond reach.

Synthetic Methylotrophy in Yeasts: Towards a Circular Bioeconomy.

Mitigating climate change is a key driver for the development of sustainable and CO-neutral production processes. In this regard, connecting carbon capture and utilization processes to derive microbial C fermentation substrates from CO is highly promising. This strategy uses methylotrophic microbes to unlock next-generation processes, converting CO-derived methanol.